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Tchem
GLRA3
Glycine receptor subunit alpha-3

Protein Classes
Protein Summary
Description
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274093
  • ENSP00000274093
  • ENSG00000145451
  • ENST00000340217
  • ENSP00000345284
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
molecular function
0.96
protein domain
0.92
microRNA
0.7
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.06   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 90   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.06   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 90   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive symptom measurement
1
1
1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive symptom measurement
1
29.5
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (126)
1 – 10 of 126
KCTD2
Tdark
Novelty: 0.42992811
p_int: 0.982674931
p_ni: 0.017309382
p_wrong: 0.000015687
Score: 0.39
Data Source: BioPlex,STRINGDB
GPHN
Tbio
Novelty: 0.0020752
Score: 0.971
Data Source: STRINGDB
GARS
Tbio
Family: Enzyme
Novelty: 0.00190498
Score: 0.922
Data Source: STRINGDB
GLRB
Tclin
Family: IC
Novelty: 0.01721113
Score: 0.906
Data Source: Reactome,STRINGDB
ANO6
Tbio
Family: IC
Novelty: 0.01288434
Score: 0.902
Data Source: STRINGDB
GLRA2
Tchem
Family: IC
Novelty: 0.02839305
Score: 0.883
Data Source: STRINGDB
GLRA4
Tdark
Family: IC
Novelty: 0.07586108
Score: 0.881
Data Source: STRINGDB
GRIN3B
Tclin
Family: IC
Novelty: 0.02261519
Score: 0.8
Data Source: STRINGDB
GRIN3A
Tclin
Family: IC
Novelty: 0.00877072
Score: 0.8
Data Source: STRINGDB
BEST1
Tbio
Family: IC
Novelty: 0.0026324
Score: 0.774
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.06

PubMed score by year
PubTator Score  24.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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