GLRA3
Glycine receptor subunit alpha-3
Protein Summary
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:9677400, PubMed:26416729). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). This gene encodes a member of the ligand-gated ion channel protein family. The encoded protein is a member of the glycine receptor subfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
- ENST00000274093
- ENSP00000274093
- ENSG00000145451
- ENST00000340217
- ENSP00000345284
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.96 | ||
molecular function | 0.96 | ||
protein domain | 0.92 | ||
microRNA | 0.7 | ||
cell type or tissue | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.41 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 90 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.41 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 90 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4