NDUFS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.98 | ||
disease perturbation | 0.97 | ||
virus perturbation | 0.96 | ||
interacting protein | 0.88 | ||
molecular function | 0.86 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Complex I biogenesis | ||||
Reactome | Metabolism | ||||
Reactome | Respiratory electron transport | ||||
Reactome | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Complex I biogenesis | ||||
Metabolism | ||||
Respiratory electron transport | ||||
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
blood protein measurement | 1 | 5 | 5 | 94.7 | |||||
serum non-albumin protein measurement | 1 | 4 | 4 | 93.7 | |||||
mean platelet volume | 3 | 2 | 4 | 93 | |||||
blood metabolite measurement | 2 | 2 | 2 | 83 | |||||
4 | 2 | 0 | 1.1 | 82.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
blood protein measurement | 5 | 94.7 | |||||
serum non-albumin protein measurement | 4 | 93.7 | |||||
mean platelet volume | 4 | 93 | |||||
blood metabolite measurement | 2 | 83 | |||||
0 | 1.1 | 82.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase core subunit S2 | VGNC:8078 | 747334 | |||||
Macaque | NADH:ubiquinone oxidoreductase core subunit S2 | 719935 | ||||||
Mouse | MGI:2385112 | 226646 | ||||||
Rat | RGD:1307109 | 289218 | ||||||
Dog | NADH:ubiquinone oxidoreductase core subunit S2 | VGNC:43707 | 478981 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | NADH:ubiquinone oxidoreductase core subunit S2 | |||||
Macaque | NADH:ubiquinone oxidoreductase core subunit S2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | NADH:ubiquinone oxidoreductase core subunit S2 | |||||
PMID | Year | Title |
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