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Tclin
NDUFS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:12611891). The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript varian ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367993
  • ENSP00000356972
  • ENSG00000158864
  • ENST00000392179
  • ENSP00000376018

Symbol
  • CI-49
  • MC1DN6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.97
virus perturbation
0.96
interacting protein
0.88
molecular function
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.6   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.6   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
67.5
granulocyte percentage of myeloid white cells
1
1
1
22
mean corpuscular hemoglobin concentration
1
1
1
9.3
eosinophil percentage of leukocytes
1
1
1
7.8
leukocyte count
1
1
1
2.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
67.5
granulocyte percentage of myeloid white cells
1
22
mean corpuscular hemoglobin concentration
1
9.3
eosinophil percentage of leukocytes
1
7.8
leukocyte count
1
2.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S2
VGNC:8078
747334
Macaque
NADH:ubiquinone oxidoreductase core subunit S2
719935
Mouse
MGI:2385112
226646
Rat
RGD:1307109
289218
Dog
NADH:ubiquinone oxidoreductase core subunit S2
VGNC:43707
478981
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S2
Macaque
NADH:ubiquinone oxidoreductase core subunit S2
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit S2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75306-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (203)
1 – 10 of 203
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.998628581
p_ni: 0.001371419
Score: 0.991
Data Source: BioPlex,STRINGDB
NDUFAF4
Tclin
Family: Enzyme
Novelty: 0.10799507
p_int: 0.997353677
p_ni: 0.002646323
Score: 0.971
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.957486785
p_ni: 0.042513215
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.905039117
p_ni: 0.094960883
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.875635597
p_ni: 0.124364403
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.855353117
p_ni: 0.144646883
Score: 0.995
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.849888235
p_ni: 0.150111765
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF3
Tclin
Family: Enzyme
Novelty: 0.00063584
Score: 0.999
Data Source: STRINGDB
NDUFA6
Tclin
Family: Enzyme
Novelty: 0.01236094
Score: 0.999
Data Source: STRINGDB
NDUFV2
Tclin
Family: Enzyme
Novelty: 0.02240263
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.60

PubMed score by year
PubTator Score  41.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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