Tclin NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:12611891). The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• O75306
• D3DVG7
• J3KPM7
• Q5VTW0
• Q969P3
• Q9UEV3

Gene Name

• NDUFS2

Ensembl ID

• ENST00000367993
• ENSP00000356972
• ENSG00000158864
• ENST00000392179
• ENSP00000376018

Symbol

• CI-49
• MC1DN6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.97
virus perturbation	0.96
interacting protein	0.88
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 2, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 2, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1