Tclin NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:12611891). The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• O75306
• D3DVG7
• J3KPM7
• Q5VTW0
• Q969P3
• Q9UEV3

Gene Name

• NDUFS2

Ensembl ID

• ENST00000367993
• ENSP00000356972
• ENSG00000158864
• ENST00000392179
• ENSP00000376018

Symbol

• CI-49
• MC1DN6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.98
disease perturbation	0.97
virus perturbation	0.96
interacting protein	0.88
molecular function	0.86

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 2, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 2, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 2, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 254   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.85   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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metformin

NDUFS2Tclin Enzyme

INHIBITOR :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (203)

Explore Interacting Targets

1 – 10 of 203

• See Interactions on String-DB

NDUFV3

Tclin

Family:  Enzyme

Novelty:  0.15352039

p_int:  0.998628581

p_ni:  0.001371419

Score:  0.991

Data Source:  BioPlex,STRINGDB

NDUFAF4

Tclin

Family:  Enzyme

Novelty:  0.10799507

p_int:  0.997353677

p_ni:  0.002646323

Score:  0.971

Data Source:  BioPlex,STRINGDB

NDUFS3

Tclin

Family:  Enzyme

Novelty:  0.01968313

p_int:  0.957486785

p_ni:  0.042513215

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFA7

Tclin

Family:  Enzyme

Novelty:  0.16417588

p_int:  0.905039117

p_ni:  0.094960883

Score:  0.997

Data Source:  BioPlex,STRINGDB

NDUFA8

Tclin

Family:  Enzyme

Novelty:  0.05772867

p_int:  0.875635597

p_ni:  0.124364403

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB11

Tclin

Family:  Enzyme

Novelty:  0.0401232

p_int:  0.855353117

p_ni:  0.144646883

Score:  0.995

Data Source:  BioPlex,STRINGDB

NDUFS6

Tclin

Family:  Enzyme

Novelty:  0.07910252

p_int:  0.849888235

p_ni:  0.150111765

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFAF3

Tclin

Family:  Enzyme

Novelty:  0.00063584

Score:  0.999

Data Source:  STRINGDB

NDUFA6

Tclin

Family:  Enzyme

Novelty:  0.01236094

Score:  0.999

Data Source:  STRINGDB

NDUFV2

Tclin

Family:  Enzyme

Novelty:  0.02240263

Score:  0.999

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (5)

KEGG (8)

PathwayCommons (1)

WikiPathways (4)

Complex I biogenesis (R-HSA-6799198)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (7)

Components (4)

Processes (4)

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Items per page:

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1 – 7 of 7

GO Term	Evidence	Assigned by
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	ParkinsonsUK-UCL
electron transfer activity	Non-traceable Author Statement (NAS)	UniProtKB
NADH dehydrogenase (ubiquinone) activity	Non-traceable Author Statement (NAS)	UniProtKB
4 iron, 4 sulfur cluster binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
NAD binding	Inferred from Electronic Annotation (IEA)	InterPro
quinone binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (39)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	2	2	2		92.2
high density lipoprotein cholesterol measurement	EFO_0004612	32	3	32		92
allergic rhinitis	EFO_0005854	4	2	0	1.1	90
blood protein measurement	EFO_0007937	5	9	9		88
serum non-albumin protein measurement	EFO_0004568	1	4	4		85.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	2		92.2
high density lipoprotein cholesterol measurement	EFO_0004612	32		92
allergic rhinitis	EFO_0005854	0	1.1	90
blood protein measurement	EFO_0007937	9		88
serum non-albumin protein measurement	EFO_0004568	4		85.3

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UniProt Keyword Find Similar Targets

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3D-structure
4Fe-4S
Acetylation
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Iron
Iron-sulfur
Membrane

GWAS Trait Find Similar Targets

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allergic disease
allergic rhinitis
Alzheimer disease
asthma
blood metabolite measurement
blood protein measurement
childhood onset asthma
cholesterol:total lipids ratio
cholesteryl ester measurement
cholesteryl esters:total lipids ratio

MGI Phenotype Find Similar Targets

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embryo phenotype
growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase core subunit S2	VGNC:8078	747334
Macaque	NADH:ubiquinone oxidoreductase core subunit S2		719935
Mouse	NADH:ubiquinone oxidoreductase core subunit S2	MGI:2385112	226646
Rat	NADH:ubiquinone oxidoreductase core subunit S2	RGD:1307109	289218
Dog	NADH:ubiquinone oxidoreductase core subunit S2	VGNC:43707	478981

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase core subunit S2
Macaque	NADH:ubiquinone oxidoreductase core subunit S2
Mouse	NADH:ubiquinone oxidoreductase core subunit S2
Rat	NADH:ubiquinone oxidoreductase core subunit S2
Dog	NADH:ubiquinone oxidoreductase core subunit S2

Publication Statistics

PubMed Score 53.85

PubMed score by year

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PubTator Score 41.72

PubTator score by year

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Related Publications

Text Mined References (40)

GeneRif Annotations (9)

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PMID	Year	Title