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Tbio
RTN2
Reticulon-2

Protein Summary
Description
This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245923
  • ENSP00000245923
  • ENSG00000125744
  • ENST00000344680
  • ENSP00000345127
  • ENST00000430715
  • ENSP00000398178

Symbol
  • NSPL1
  • NSP2
  • NSPL1
  • NSPLI
  • SPG12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.78
tissue sample
0.69
cellular component
0.67
transcription factor binding site profile
0.63
transcription factor
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.65   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.65   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (106)
1 – 10 of 106
RTN1
Tbio
Novelty: 0.02399548
p_int: 0.999954009
p_ni: 0.000045983
p_wrong: 8e-9
Score: 0.648
Data Source: BioPlex,STRINGDB
RTN4
Tbio
Novelty: 0.00025114
p_int: 0.999906476
p_ni: 0.000093394
p_wrong: 1.3e-7
Score: 0.653
Data Source: BioPlex,STRINGDB
FAM241A
Tdark
Novelty: 2.7184466
p_int: 0.999860008
p_ni: 0.000139972
p_wrong: 2e-8
Data Source: BioPlex
TMEM128
Tdark
p_int: 0.9996495
p_ni: 0.000350493
p_wrong: 7e-9
Score: 0.195
Data Source: BioPlex,STRINGDB
C11orf87
Tdark
p_int: 0.999364709
p_ni: 0.000580998
p_wrong: 0.000054293
Data Source: BioPlex
FPR2
Tchem
Family: GPCR
Novelty: 0.00286277
p_int: 0.995884408
p_ni: 0.004115526
p_wrong: 6.6e-8
Data Source: BioPlex
SVOPL
Tdark
Novelty: 0.85069312
p_int: 0.99326962
p_ni: 0.00670502
p_wrong: 0.00002536
Data Source: BioPlex
VTN
Tbio
Family: TF
Novelty: 0.00057817
p_int: 0.99286926
p_ni: 0.005076105
p_wrong: 0.002054635
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.004102
p_int: 0.988957597
p_ni: 0.009879354
p_wrong: 0.001163049
Data Source: BioPlex
GYPB
Tbio
Novelty: 0.00257625
p_int: 0.988533694
p_ni: 0.00590674
p_wrong: 0.005559567
Data Source: BioPlex
Publication Statistics
PubMed Score  7.65

PubMed score by year
PubTator Score  271.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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