GADD45B
Growth arrest and DNA damage-inducible protein GADD45 beta
Protein Summary
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
- ENST00000215631
- ENSP00000215631
- ENSG00000099860
- MYD118
- MYD118
- GADD45BETA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
PubMedID | 0.99 | ||
transcription factor perturbation | 0.99 | ||
transcription factor binding site profile | 0.97 | ||
disease perturbation | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 187.26 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 147 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 187.26 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 147 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (89)
CNOT2
Novelty: 0.01886737
p_int: 0.999639365
p_ni: 0.000360635
Score: 0.558
Data Source: BioPlex,STRINGDB
CNOT6
Novelty: 0.03605299
p_int: 0.99943992
p_ni: 0.00056008
Score: 0.747
Data Source: BioPlex,STRINGDB
IL36A
Novelty: 0.03569425
p_int: 0.999407411
p_ni: 0.000592589
Score: 0.211
Data Source: BioPlex,STRINGDB
CNOT6L
Novelty: 0.06038336
p_int: 0.999331931
p_ni: 0.000668069
Score: 0.549
Data Source: BioPlex,STRINGDB
CNOT8
Novelty: 0.01700084
p_int: 0.999030141
p_ni: 0.000969859
Score: 0.54
Data Source: BioPlex,STRINGDB
CNOT11
Novelty: 0.01687183
p_int: 0.999018231
p_ni: 0.000981769
Score: 0.807
Data Source: BioPlex,STRINGDB
CNOT1
Novelty: 0.00362753
p_int: 0.997512871
p_ni: 0.002487129
Score: 0.787
Data Source: BioPlex,STRINGDB
CNOT10
Novelty: 0.30195594
p_int: 0.997106393
p_ni: 0.002893607
Score: 0.787
Data Source: BioPlex,STRINGDB
CNOT9
Novelty: 0.05592835
p_int: 0.995473451
p_ni: 0.004526549
Score: 0.6
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
MAP2K1
MAP2K2
Pathways (37)
KEGG (23)
PathwayCommons (3)
WikiPathways (11)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Non-small cell lung cancer | ||||
KEGG | Chronic myeloid leukemia | ||||
KEGG | Gastric cancer | ||||
KEGG | Melanoma | ||||
KEGG | Cell cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Non-small cell lung cancer | ||||
Chronic myeloid leukemia | ||||
Gastric cancer | ||||
Melanoma | ||||
Cell cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Components (2)
Processes (10)
Disease Associations ()
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 1 | 2 | 78.1 | |||||
age-related hearing impairment | 1 | 1 | 0 | 5.9 | 30.2 | ||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 78.1 | |||||
age-related hearing impairment | 0 | 5.9 | 30.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | growth arrest and DNA damage inducible beta | 711257 | ||||||
Mouse | MGI:107776 | 17873 | ||||||
Rat | RGD:1309080 | 299626 | ||||||
Dog | growth arrest and DNA damage inducible beta | VGNC:41070 | 485069 | |||||
Horse | growth arrest and DNA damage inducible beta | VGNC:18208 | 100059768 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | growth arrest and DNA damage inducible beta | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth arrest and DNA damage inducible beta | |||||
Horse | growth arrest and DNA damage inducible beta | |||||
Publication Statistics
PubMed Score 187.26
PubMed score by year
PubTator Score 81.31
PubTator score by year
Related Publications
Text Mined References (61)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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