Tclin NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75251
• B3KRI2
• Q2T9H7
• Q9BV17

Gene Name

• NDUFS7

Ensembl ID

• ENST00000233627
• ENSP00000233627
• ENSG00000115286
• ENST00000313408
• ENSP00000364262
• ENST00000546283
• ENSP00000440348

Symbol

• PSST
• CI-20
• MY017
• MC1DN3
• CI-20KD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
cellular component	0.83
histone modification site profile	0.77
disease perturbation	0.74
molecular function	0.7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 924.9   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 924.9   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Approved Drugs (1)

Explore Approved Drugs

1 – 1 of 1

metformin

NDUFS7Tclin Enzyme

INHIBITOR :

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (16)

Reactome (5)

KEGG (8)

WikiPathways (3)

Complex I biogenesis (R-HSA-6799198)

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5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Gene Ontology Terms (15)

Functions (6)

Components (5)

Processes (4)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
NADH dehydrogenase (ubiquinone) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Non-traceable Author Statement (NAS)	UniProtKB
4 iron, 4 sulfur cluster binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protease binding	Inferred from Electronic Annotation (IEA)	Ensembl
quinone binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (249)

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1 – 10 of 249

• See Interactions on String-DB

ALKBH7

Tbio

Family: Enzyme

Novelty: 0.2708486

p_int: 0.999986598

p_ni: 1.52e-7

p_wrong: 0.00001325

Score: 0.332

Data Source: BioPlex,STRINGDB

HEMK1

Tbio

Family: Enzyme

Novelty: 0.05529954

p_int: 0.999932669

p_ni: 0.000063479

p_wrong: 0.000003852

Data Source: BioPlex

PDP2

Tbio

Family: Enzyme

Novelty: 0.03885526

p_int: 0.999817919

p_ni: 0.000166344

p_wrong: 0.000015737

Data Source: BioPlex

NDUFB7

Tclin

Family: Enzyme

Novelty: 0.37890274

p_int: 0.999677539

p_ni: 0.000315503

p_wrong: 0.000006957

Score: 0.999

Data Source: BioPlex,STRINGDB

NDUFAF5

Tbio

Family: Enzyme

Novelty: 0.19033233

p_int: 0.999586419

p_ni: 0.00041358

Score: 0.996

Data Source: BioPlex,STRINGDB

NDUFB5

Tclin

Family: Enzyme

Novelty: 0.03732485

p_int: 0.999415771

p_ni: 0.000584229

Score: 0.999

Data Source: BioPlex,STRINGDB

VARS2

Tbio

Family: Enzyme

Novelty: 0.0110026

p_int: 0.99937054

p_ni: 0.000297948

p_wrong: 0.000331513

Score: 0.245

Data Source: BioPlex,STRINGDB

NDUFB6

Tclin

Family: Enzyme

Novelty: 0.12942989

p_int: 0.999308632

p_ni: 0.000293775

p_wrong: 0.000397594

Score: 0.999

Data Source: BioPlex,STRINGDB

ACSS1

Tbio

Family: Enzyme

Novelty: 0.03182902

p_int: 0.999128437

p_ni: 0.000303177

p_wrong: 0.000568386

Score: 0.347

Data Source: BioPlex,STRINGDB

NDUFS4

Tclin

Family: Enzyme

Novelty: 0.00092949

p_int: 0.999054255

p_ni: 0.000728495

p_wrong: 0.000217249

Score: 0.999

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  924.90

PubMed score by year

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PubTator Score  161.49

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
4Fe-4S
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Hydroxylation
Iron
Iron-sulfur
Leigh syndrome

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging