Tclin NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Protein Summary

Description

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75251
• B3KRI2
• Q2T9H7
• Q9BV17

Gene Name

• NDUFS7

Ensembl ID

• ENST00000233627
• ENSP00000233627
• ENSG00000115286
• ENST00000313408
• ENSP00000364262
• ENST00000546283
• ENSP00000440348

Symbol

• PSST
• CI-20
• MY017
• MC1DN3
• CI-20KD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.97
cellular component	0.83
histone modification site profile	0.77
disease perturbation	0.74
molecular function	0.7

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

Protein / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Nadh Dehydrogenase [Ubiquinone] Iron-sulfur Protein 7, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.67   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 142   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.67   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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metformin

NDUFS7Tclin Enzyme

INHIBITOR :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (249)

Explore Interacting Targets

1 – 10 of 249

• See Interactions on String-DB

ALKBH7

Tbio

Family:  Enzyme

Novelty:  0.12865849

p_int:  0.999986598

p_ni:  1.52e-7

p_wrong:  0.00001325

Score:  0.332

Data Source:  BioPlex,STRINGDB

HEMK1

Tbio

Family:  Enzyme

Novelty:  0.03509926

p_int:  0.999932669

p_ni:  0.000063479

p_wrong:  0.000003852

Data Source:  BioPlex

PDP2

Tbio

Family:  Enzyme

Novelty:  0.0259516

p_int:  0.999817919

p_ni:  0.000166344

p_wrong:  0.000015737

Data Source:  BioPlex

NDUFB7

Tclin

Family:  Enzyme

Novelty:  0.14580093

p_int:  0.999677539

p_ni:  0.000315503

p_wrong:  0.000006957

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFAF5

Tbio

Family:  Enzyme

Novelty:  0.13483499

p_int:  0.999586419

p_ni:  0.00041358

Score:  0.996

Data Source:  BioPlex,STRINGDB

NDUFB5

Tclin

Family:  Enzyme

Novelty:  0.0257403

p_int:  0.999415771

p_ni:  0.000584229

Score:  0.999

Data Source:  BioPlex,STRINGDB

VARS2

Tbio

Family:  Enzyme

Novelty:  0.00941946

p_int:  0.99937054

p_ni:  0.000297948

p_wrong:  0.000331513

Score:  0.245

Data Source:  BioPlex,STRINGDB

NDUFB6

Tclin

Family:  Enzyme

Novelty:  0.075245

p_int:  0.999308632

p_ni:  0.000293775

p_wrong:  0.000397594

Score:  0.999

Data Source:  BioPlex,STRINGDB

ACSS1

Tbio

Family:  Enzyme

Novelty:  0.02003886

p_int:  0.999128437

p_ni:  0.000303177

p_wrong:  0.000568386

Score:  0.347

Data Source:  BioPlex,STRINGDB

NDUFS4

Tclin

Family:  Enzyme

Novelty:  0.00787292

p_int:  0.999054255

p_ni:  0.000728495

p_wrong:  0.000217249

Score:  0.999

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (16)

Reactome (5)

KEGG (8)

WikiPathways (3)

Complex I biogenesis (R-HSA-6799198)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Functions (6)

Components (5)

Processes (4)

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Items per page:

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1 – 6 of 6

GO Term	Evidence	Assigned by
NADH dehydrogenase (ubiquinone) activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	Non-traceable Author Statement (NAS)	UniProtKB
4 iron, 4 sulfur cluster binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
protease binding	Inferred from Electronic Annotation (IEA)	Ensembl
quinone binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (3)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	1	1	1		13.5
hematocrit	EFO_0004348	1	1	1		13.5
pulse pressure measurement	EFO_0005763	1	1	1		12.6

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
hemoglobin measurement	EFO_0004509	1		13.5
hematocrit	EFO_0004348	1		13.5
pulse pressure measurement	EFO_0005763	1		12.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
4Fe-4S
Alternative splicing
Complete proteome
Disease mutation
Electron transport
Hydroxylation
Iron
Iron-sulfur
Leigh syndrome

GWAS Trait Find Similar Targets

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hematocrit
hemoglobin measurement
pulse pressure measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
embryo phenotype
growth/size/body region phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase core subunit S7	VGNC:11199	100126358
Macaque	NADH:ubiquinone oxidoreductase core subunit S7		721259
Mouse	NADH:ubiquinone oxidoreductase core subunit S7	MGI:1922656	75406
Rat	NADH:ubiquinone oxidoreductase core subunit S7	RGD:1310013	362837
Dog	NADH:ubiquinone oxidoreductase core subunit S7	VGNC:43710	476754

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase core subunit S7
Macaque	NADH:ubiquinone oxidoreductase core subunit S7
Mouse	NADH:ubiquinone oxidoreductase core subunit S7
Rat	NADH:ubiquinone oxidoreductase core subunit S7
Dog	NADH:ubiquinone oxidoreductase core subunit S7

Publication Statistics

PubMed Score 62.67

PubMed score by year

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PubTator Score 161.49

PubTator score by year

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Related Publications

Text Mined References (23)

GeneRif Annotations (7)

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10

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PMID	Year	Title