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Tclin
NDUFS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233627
  • ENSP00000233627
  • ENSG00000115286
  • ENST00000313408
  • ENSP00000364262
  • ENST00000546283
  • ENSP00000440348

Symbol
  • PSST
  • CI-20
  • MY017
  • MC1DN3
  • CI-20KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
cellular component
0.83
histone modification site profile
0.77
disease perturbation
0.74
molecular function
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.65   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.65   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S7
VGNC:11199
100126358
Macaque
NADH:ubiquinone oxidoreductase core subunit S7
721259
Mouse
MGI:1922656
75406
Rat
RGD:1310013
362837
Dog
NADH:ubiquinone oxidoreductase core subunit S7
VGNC:43710
476754
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit S7
Macaque
NADH:ubiquinone oxidoreductase core subunit S7
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit S7
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75251-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (249)
1 – 10 of 249
ALKBH7
Tbio
Family: Enzyme
Novelty: 0.12865849
p_int: 0.999986598
p_ni: 1.52e-7
p_wrong: 0.00001325
Score: 0.332
Data Source: BioPlex,STRINGDB
HEMK1
Tbio
Family: Enzyme
Novelty: 0.03509926
p_int: 0.999932669
p_ni: 0.000063479
p_wrong: 0.000003852
Data Source: BioPlex
PDP2
Tbio
Family: Enzyme
Novelty: 0.0259516
p_int: 0.999817919
p_ni: 0.000166344
p_wrong: 0.000015737
Data Source: BioPlex
NDUFB7
Tclin
Family: Enzyme
Novelty: 0.14580093
p_int: 0.999677539
p_ni: 0.000315503
p_wrong: 0.000006957
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF5
Tbio
Family: Enzyme
Novelty: 0.13483499
p_int: 0.999586419
p_ni: 0.00041358
Score: 0.996
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999415771
p_ni: 0.000584229
Score: 0.999
Data Source: BioPlex,STRINGDB
VARS2
Tbio
Family: Enzyme
Novelty: 0.00941946
p_int: 0.99937054
p_ni: 0.000297948
p_wrong: 0.000331513
Score: 0.245
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.999308632
p_ni: 0.000293775
p_wrong: 0.000397594
Score: 0.999
Data Source: BioPlex,STRINGDB
ACSS1
Tbio
Family: Enzyme
Novelty: 0.02003886
p_int: 0.999128437
p_ni: 0.000303177
p_wrong: 0.000568386
Score: 0.347
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999054255
p_ni: 0.000728495
p_wrong: 0.000217249
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  62.65

PubMed score by year
PubTator Score  161.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer