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Tclin
NDUFS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

Protein Classes
Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233627
  • ENSP00000233627
  • ENSG00000115286
  • ENST00000313408
  • ENSP00000364262
  • ENST00000546283
  • ENSP00000440348

Symbol
  • PSST
  • CI-20
  • MY017
  • MC1DN3
  • CI-20KD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
cellular component
0.83
histone modification site profile
0.77
disease perturbation
0.74
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 924.9   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 924.9   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (15)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (249)
1 – 10 of 249
ALKBH7
Tbio
Family: Enzyme
Novelty: 0.2708486
p_int: 0.999986598
p_ni: 1.52e-7
p_wrong: 0.00001325
Score: 0.332
Data Source: BioPlex,STRINGDB
HEMK1
Tbio
Family: Enzyme
Novelty: 0.05529954
p_int: 0.999932669
p_ni: 0.000063479
p_wrong: 0.000003852
Data Source: BioPlex
PDP2
Tbio
Family: Enzyme
Novelty: 0.03885526
p_int: 0.999817919
p_ni: 0.000166344
p_wrong: 0.000015737
Data Source: BioPlex
NDUFB7
Tclin
Family: Enzyme
Novelty: 0.37890274
p_int: 0.999677539
p_ni: 0.000315503
p_wrong: 0.000006957
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFAF5
Tbio
Family: Enzyme
Novelty: 0.19033233
p_int: 0.999586419
p_ni: 0.00041358
Score: 0.996
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.03732485
p_int: 0.999415771
p_ni: 0.000584229
Score: 0.999
Data Source: BioPlex,STRINGDB
VARS2
Tbio
Family: Enzyme
Novelty: 0.0110026
p_int: 0.99937054
p_ni: 0.000297948
p_wrong: 0.000331513
Score: 0.245
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.12942989
p_int: 0.999308632
p_ni: 0.000293775
p_wrong: 0.000397594
Score: 0.999
Data Source: BioPlex,STRINGDB
ACSS1
Tbio
Family: Enzyme
Novelty: 0.03182902
p_int: 0.999128437
p_ni: 0.000303177
p_wrong: 0.000568386
Score: 0.347
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00092949
p_int: 0.999054255
p_ni: 0.000728495
p_wrong: 0.000217249
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  924.90

PubMed score by year
PubTator Score  161.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer