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Tbio
XYLB
Xylulose kinase

Protein Summary
Description
Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000207870
  • ENSP00000207870
  • ENSG00000093217
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
cell type or tissue
0.79
tissue sample
0.7
disease perturbation
0.68
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Formation of xylulose-5-phosphate (R-HSA-5661270)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Formation of xylulose-5-phosphate
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Formation of xylulose-5-phosphate
Metabolism
Metabolism of carbohydrates
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (92)
1 – 10 of 92
RPE
Tbio
Family: Enzyme
Novelty: 0.00825452
Score: 0.983
Data Source: STRINGDB
RPEL1
Tbio
Family: Enzyme
Novelty: 0.67708333
Score: 0.965
Data Source: STRINGDB
SLC22A14
Tdark
Family: Transporter
Novelty: 0.35477513
Score: 0.931
Data Source: STRINGDB
TALDO1
Tbio
Family: Enzyme
Novelty: 0.00254889
Score: 0.928
Data Source: STRINGDB
SLC22A13
Tbio
Family: Transporter
Novelty: 0.05026745
Score: 0.911
Data Source: STRINGDB
XDH
Tclin
Family: Enzyme
Novelty: 0.00097175
Score: 0.875
Data Source: STRINGDB
SORD
Tchem
Family: Enzyme
Novelty: 0.00508278
Score: 0.858
Data Source: STRINGDB
TKT
Tchem
Family: Enzyme
Novelty: 0.0027011
Score: 0.809
Data Source: STRINGDB
OXSR1
Tbio
Family: Kinase
Novelty: 0.22453889
Score: 0.8
Data Source: STRINGDB
AKR1B1
Tclin
Family: Enzyme
Novelty: 0.00050572
Score: 0.784
Data Source: STRINGDB
Publication Statistics
PubMed Score  114.72

PubMed score by year
PubTator Score  12.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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