Tbio XYLB Xylulose kinase

Protein Summary

Description

Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]

Uniprot Accession IDs

• O75191
• B2RAW4
• B4DDT2
• B9EH64
• Xylulokinase

Gene Name

• XYLB

Ensembl ID

• ENST00000207870
• ENSP00000207870
• ENSG00000093217

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
cell type or tissue	0.79
tissue sample	0.7
disease perturbation	0.68
transcription factor perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Carbohydrate Kinase / Xylulose Kinase

DTO Classes

Protein / Kinase / Unclassified Protein / Xylulose Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.59   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 79   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 216.59   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0