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Tbio
DNAJB6
DnaJ homolog subfamily B member 6

Protein Summary
Description
Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262177
  • ENSP00000262177
  • ENSG00000105993
  • ENST00000429029
  • ENSP00000397556

Symbol
  • HSJ2
  • MRJ
  • MSJ1
  • DJ4
  • MRJ
  • DnaJ
  • HSJ2
  • HHDJ1
  • HSJ-2
  • MSJ-1
  • LGMD1D
  • LGMD1E
  • LGMDD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.91
transcription factor perturbation
0.91
transcription factor binding site profile
0.86
virus perturbation
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.19   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.19   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
1
1.1
39.4
mean corpuscular hemoglobin concentration
1
1
1
9.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
39.4
mean corpuscular hemoglobin concentration
1
9.8
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member B6
693305
Mouse
MGI:1344381
23950
Rat
RGD:1308207
362293
Dog
DnaJ heat shock protein family (Hsp40) member B6
VGNC:51797
608937
Cow
DnaJ heat shock protein family (Hsp40) member B6
VGNC:53635
282215
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DnaJ heat shock protein family (Hsp40) member B6
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member B6
Cow
DnaJ heat shock protein family (Hsp40) member B6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75190-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (77)
1 – 10 of 77
C12orf45
Tdark
Novelty:  3.65358593
p_int:  0.999787174
p_ni:  0.000013672
p_wrong:  0.000199153
Score:  0.54
Data Source:  BioPlex,STRINGDB
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.825705065
p_ni:  0.174294935
Score:  0.401
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.99
Data Source:  STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.985
Data Source:  Reactome,STRINGDB
HSPA14
Tbio
Novelty:  0.01714625
Score:  0.982
Data Source:  STRINGDB
HSPA6
Tbio
Novelty:  0.00654285
Score:  0.978
Data Source:  STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.974
Data Source:  STRINGDB
HSPA9
Tchem
Novelty:  0.00235171
Score:  0.966
Data Source:  STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
Score:  0.965
Data Source:  STRINGDB
HSPA1B
Tbio
Novelty:  0.01429214
Score:  0.962
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  106.19

PubMed score by year
PubTator Score  59.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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