Tbio DNAJB6 DnaJ homolog subfamily B member 6

Protein Summary

Description

Plays an indispensable role in the organization of KRT8/KRT18 filaments. Acts as an endogenous molecular chaperone for neuronal proteins including huntingtin. Suppresses aggregation and toxicity of polyglutamine-containing, aggregation-prone proteins. Isoform B but not isoform A inhibits huntingtin aggregation. Has a stimulatory effect on the ATPase activity of HSP70 in a dose-dependent and time-dependent manner and hence acts as a co-chaperone of HSP70. Also reduces cellular toxicity and caspase-3 activity. This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75190
• A4D232
• A8K7D8
• A8KAG0
• B4DN73
• E9PCZ2
• O95806
• Q53EN8
• Q59EF2
• Q6FIC8
• Q75MA2
• Q9UIK6

Gene Name

• DNAJB6

Ensembl ID

• ENST00000262177
• ENSP00000262177
• ENSG00000105993
• ENST00000429029
• ENSP00000397556

Symbol

• HSJ2
• MRJ
• MSJ1
• DJ4
• MRJ
• DnaJ
• HSJ2
• HHDJ1
• HSJ-2
• MSJ-1
• LGMD1D
• LGMD1E
• LGMDD1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.91
transcription factor perturbation	0.91
transcription factor binding site profile	0.86
virus perturbation	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.95   (req: < 5)

Gene RIFs: 62   (req: <= 3)

Antibodies: 284   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.95   (req: >= 5)

Gene RIFs: 62   (req: > 3)

Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0