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Tbio
SIN3B
Paired amphipathic helix protein Sin3b

Protein Summary
Description
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248054
  • ENSP00000248054
  • ENSG00000127511
  • ENST00000379803
  • ENSP00000369131
  • ENST00000596802
  • ENSP00000473039

Symbol
  • KIAA0700
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
disease perturbation
0.97
transcription factor perturbation
0.97
biological process
0.7
molecular function
0.7


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.54   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.54   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SIN3 transcription regulator family member B
VGNC:2248
455830
Macaque
SIN3 transcription regulator family member B
718813
Mouse
MGI:107158
20467
Dog
SIN3 transcription regulator family member B
VGNC:46178
610198
Horse
SIN3 transcription regulator family member B
VGNC:22983
100069936
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SIN3 transcription regulator family member B
Macaque
SIN3 transcription regulator family member B
Mouse
Dog
SIN3 transcription regulator family member B
Horse
SIN3 transcription regulator family member B
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75182-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Epigenetic regulation of gene expression (R-HSA-212165)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Epigenetic regulation of gene expression
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
Metabolism of lipids
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (223)
1 – 10 of 223
ING2
Tbio
Family: Epigenetic
Novelty: 0.02424031
p_int: 0.999999947
p_ni: 5.3e-8
Score: 0.949
Data Source: BioPlex,STRINGDB
SUDS3
Tbio
Family: Enzyme
Novelty: 0.03837881
p_int: 0.999999817
p_ni: 1.83e-7
Score: 0.998
Data Source: BioPlex,STRINGDB
RBBP7
Tbio
Novelty: 0.01795364
p_int: 0.999998706
p_ni: 0.000001293
Score: 0.991
Data Source: BioPlex,STRINGDB
SINHCAF
Tdark
Novelty: 0.18692832
p_int: 0.999997652
p_ni: 0.000002344
p_wrong: 4e-9
Score: 0.909
Data Source: BioPlex,STRINGDB
MORF4L1
Tbio
Family: Epigenetic
Novelty: 0.01696001
p_int: 0.999985364
p_ni: 0.000014312
p_wrong: 3.25e-7
Score: 0.955
Data Source: BioPlex,STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
p_int: 0.999981675
p_ni: 0.000017536
p_wrong: 7.89e-7
Score: 0.996
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.999729173
p_ni: 0.000270827
Score: 0.231
Data Source: BioPlex,STRINGDB
PHF23
Tbio
Family: Epigenetic
Novelty: 0.17699844
p_int: 0.979856
p_ni: 0.020143992
p_wrong: 8e-9
Score: 0.771
Data Source: BioPlex,STRINGDB
RNF151
Tdark
Novelty: 2.0077961
p_int: 0.874545872
p_ni: 0.125453429
p_wrong: 7e-7
Data Source: BioPlex
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.783681161
p_ni: 0.216318431
p_wrong: 4.09e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  25.54

PubMed score by year
PubTator Score  22.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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