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Tbio
ANKRD17
Ankyrin repeat domain-containing protein 17

Protein Summary
Description
Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330838
  • ENSP00000332265
  • ENSG00000132466
  • ENST00000358602
  • ENSP00000351416
  • ENST00000509867
  • ENSP00000427151

Symbol
  • GTAR
  • KIAA0697
  • GTAR
  • MASK2
  • NY-BR-16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor binding site profile
0.92
transcription factor perturbation
0.91
co-expressed gene
0.89
histone modification site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.83   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.83   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (53)
1 – 10 of 53
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.999999487
p_ni:  5.13e-7
Data Source:  BioPlex
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
p_int:  0.999396807
p_ni:  0.000603193
Data Source:  BioPlex
HOXC4
Tbio
Family:  TF
Novelty:  0.02206351
p_int:  0.997303957
p_ni:  0.002696043
Score:  0.181
Data Source:  BioPlex,STRINGDB
AKAP17A
Tbio
Family:  Enzyme
Novelty:  0.02860381
p_int:  0.99630114
p_ni:  0.00369886
Score:  0.155
Data Source:  BioPlex,STRINGDB
FGF3
Tbio
Novelty:  0.00474087
p_int:  0.996209804
p_ni:  0.003790196
Data Source:  BioPlex
FGF8
Tbio
Novelty:  0.00155113
p_int:  0.993610783
p_ni:  0.006389217
Data Source:  BioPlex
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.991692989
p_ni:  0.008307011
Data Source:  BioPlex
STX11
Tbio
Novelty:  0.01670743
p_int:  0.989228567
p_ni:  0.010771433
Data Source:  BioPlex
ZC3H3
Tbio
Novelty:  0.26894046
p_int:  0.97167079
p_ni:  0.02832921
Data Source:  BioPlex
FOSL2
Tbio
Family:  TF
Novelty:  0.00375452
p_int:  0.967387464
p_ni:  0.032612536
Score:  0.179
Data Source:  BioPlex,STRINGDB
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
1
7
74.3
total cholesterol measurement
1
1
1
67.1
hematocrit
1
1
1
35
esterified cholesterol measurement
2
1
2
35
free cholesterol measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
7
74.3
total cholesterol measurement
1
67.1
hematocrit
1
35
esterified cholesterol measurement
2
35
free cholesterol measurement
1
21.5
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 17
VGNC:557
461263
Mouse
MGI:1932101
81702
Rat
RGD:1562348
289521
Dog
ankyrin repeat domain 17
VGNC:51766
475174
Cow
ankyrin repeat domain 17
VGNC:50089
508405
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ankyrin repeat domain 17
Mouse
Rat
Dog
ankyrin repeat domain 17
Cow
ankyrin repeat domain 17
Publication Statistics
PubMed Score 32.83
PubMed score by year
PubTator Score 7.04
PubTator score by year