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Tbio
SS18L1
Calcium-responsive transactivator

Protein Summary
Description
Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). This gene encodes a calcium-responsive ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331758
  • ENSP00000333012
  • ENSG00000184402
  • ENST00000370848
  • ENSP00000359885

Symbol
  • CREST
  • KIAA0693
  • CREST
  • LP2261
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
virus perturbation
0.85
transcription factor binding site profile
0.76
biological process
0.74
microRNA
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.46   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.46   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (66)
1 – 10 of 66
SMARCD1
Tbio
Novelty: 0.04468954
p_int: 0.999997401
p_ni: 0.000002577
p_wrong: 2.2e-8
Score: 0.935
Data Source: BioPlex,STRINGDB
DPF2
Tbio
Family: Epigenetic
Novelty: 0.01184879
p_int: 0.999997182
p_ni: 0.000002815
p_wrong: 3e-9
Score: 0.933
Data Source: BioPlex,STRINGDB
DPF3
Tbio
Family: Epigenetic
Novelty: 0.09141321
p_int: 0.99275228
p_ni: 0.000002159
p_wrong: 0.007245561
Score: 0.963
Data Source: BioPlex,STRINGDB
SMARCE1
Tbio
Family: TF
Novelty: 0.02547452
p_int: 0.906771586
p_ni: 0.000015868
p_wrong: 0.093212546
Score: 0.944
Data Source: BioPlex,STRINGDB
SMARCC2
Tbio
Family: TF; Epigenetic
Novelty: 0.04842565
p_int: 0.881554264
p_ni: 0.000029061
p_wrong: 0.118416674
Score: 0.93
Data Source: BioPlex,STRINGDB
DPF1
Tbio
Family: Epigenetic
Novelty: 0.10224521
Score: 0.781
Data Source: STRINGDB
RFX6
Tbio
Family: TF
Novelty: 0.00245743
Score: 0.768
Data Source: STRINGDB
SMARCA4
Tchem
Family: Epigenetic
Novelty: 0.00120535
Score: 0.766
Data Source: STRINGDB
ACTL6B
Tbio
Novelty: 0.09956074
Score: 0.766
Data Source: STRINGDB
BICRA
Tbio
Novelty: 0.21142986
Score: 0.757
Data Source: STRINGDB
Publication Statistics
PubMed Score  7.46

PubMed score by year
PubTator Score  147.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer