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Tbio
SOCS5
Suppressor of cytokine signaling 5

Protein Summary
Description
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein ha ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306503
  • ENSP00000305133
  • ENSG00000171150
  • ENST00000394861
  • ENSP00000378330

Symbol
  • CIS6
  • CISH5
  • CISH6
  • KIAA0671
  • CIS6
  • CISH6
  • Cish5
  • SOCS-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
kinase perturbation
0.88
disease perturbation
0.87
transcription factor
0.82
transcription factor binding site profile
0.82


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.3   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.3   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999537
p_ni:  1e-9
p_wrong:  4.62e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999998421
p_ni:  6e-9
p_wrong:  0.000001572
Score:  0.944
Data Source:  BioPlex,STRINGDB
ELOC
Tbio
Novelty:  0.00964847
Score:  0.989
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.982
Data Source:  Reactome,STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.978
Data Source:  STRINGDB
ELOB
Tbio
Novelty:  0.01315739
Score:  0.977
Data Source:  STRINGDB
IL4R
Tclin
Novelty:  0.00359183
Score:  0.976
Data Source:  Reactome,STRINGDB
JAK3
Tclin
Family:  Kinase
Novelty:  0.00164278
Score:  0.976
Data Source:  STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.969
Data Source:  STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
Score:  0.957
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 4 of 4
JAK1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
JAK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
JAK3
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
TYK2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (307)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Metabolism of proteins
Reactome
Neddylation
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-4 and Interleukin-13 signaling
Metabolism of proteins
Neddylation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
77
hematocrit
2
1
2
75.6
hemoglobin measurement
2
1
2
73.9
body height
2
2
2
62
body fat distribution
1
1
1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
77
hematocrit
2
75.6
hemoglobin measurement
2
73.9
body height
2
62
body fat distribution
1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 5
VGNC:10771
459209
Mouse
MGI:2385459
56468
Rat
RGD:1564914
500616
Dog
suppressor of cytokine signaling 5
VGNC:46652
474581
Horse
suppressor of cytokine signaling 5
VGNC:23439
100053252
Species
Name
OMA
EggNOG
Inparanoid
Chimp
suppressor of cytokine signaling 5
Mouse
Rat
Dog
suppressor of cytokine signaling 5
Horse
suppressor of cytokine signaling 5
Publication Statistics
PubMed Score 83.30
PubMed score by year
PubTator Score 85.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title