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Tdark
TSC22D2
TSC22 domain family protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361875
  • ENSP00000354543
  • ENSG00000196428

Symbol
  • KIAA0669
  • TILZ4
  • TILZ4a
  • TILZ4b
  • TILZ4c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
virus perturbation
0.76
small molecule perturbation
0.72
microRNA
0.7
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.22   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.999999993
p_ni:  2e-9
p_wrong:  5e-9
Score:  0.719
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.999999083
p_ni:  9e-9
p_wrong:  9.08e-7
Score:  0.795
Data Source:  BioPlex,STRINGDB
TSC22D3
Tbio
Family:  TF
Novelty:  0.00660285
p_int:  0.999998718
p_ni:  0.000001282
Score:  0.866
Data Source:  BioPlex,STRINGDB
FAM117B
Tdark
Novelty:  1.06316483
p_int:  0.999958902
p_ni:  0.000041043
p_wrong:  5.5e-8
Score:  0.821
Data Source:  BioPlex,STRINGDB
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.999292745
p_ni:  0.000701809
p_wrong:  0.000005445
Data Source:  BioPlex
LHX4
Tbio
Family:  TF
Novelty:  0.02047732
Score:  0.711
Data Source:  STRINGDB
RAP2B
Tbio
Family:  Enzyme
Novelty:  0.00347321
Score:  0.67
Data Source:  STRINGDB
PSAPL1
Tdark
Novelty:  0.82322044
Score:  0.649
Data Source:  STRINGDB
LHX3
Tbio
Family:  TF
Novelty:  0.00784158
Score:  0.64
Data Source:  STRINGDB
ZNF655
Tbio
Family:  TF
Novelty:  0.02852796
Score:  0.567
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
6
7
90.6
waist-hip ratio
3
5
6
89.7
BMI-adjusted waist-hip ratio
3
5
6
89.7
high density lipoprotein cholesterol measurement
2
3
3
87.4
triglyceride measurement
3
2
3
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
7
90.6
waist-hip ratio
6
89.7
BMI-adjusted waist-hip ratio
6
89.7
high density lipoprotein cholesterol measurement
3
87.4
triglyceride measurement
3
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1919283
72033
Rat
RGD:1593169
499624
Dog
TSC22 domain family member 2
VGNC:47893
477111
Cow
TSC22 domain family member 2
VGNC:36409
541277
Pig
TSC22 domain family member 2
100155608
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
TSC22 domain family member 2
Cow
TSC22 domain family member 2
Pig
TSC22 domain family member 2
Publication Statistics
PubMed Score 3.22
PubMed score by year
PubTator Score 1.26
PubTator score by year
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Related Publications
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PMID
Year
Title