Tbio RAB11FIP3 Rab11 family-interacting protein 3

Protein Summary

Description

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O75154
• B0QYI8
• B0QYT8
• B1AHQ0
• B4DEI7
• B4DZR6
• Q4VXV7
• Q7Z5E9
• Q9H155
• Q9H1G0
• Q9NUI0
• FIP3-Rab11

Gene Name

• RAB11FIP3

Ensembl ID

• ENST00000262305
• ENSP00000262305
• ENSG00000090565
• ENST00000450428
• ENSP00000415919
• ENST00000610934
• ENSP00000484620
• ENSG00000275338
• ENST00000611004
• ENSP00000482156

Symbol

• ARFO1
• KIAA0665
• CART1
• Rab11-FIP3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.79
cellular component	0.76
transcription factor binding site profile	0.75
transcription factor	0.73
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.03   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 86   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.03   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0