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Tbio
RAB11FIP3
Rab11 family-interacting protein 3

Protein Summary
Description
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of m ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262305
  • ENSP00000262305
  • ENSG00000090565
  • ENST00000450428
  • ENSP00000415919
  • ENST00000610934
  • ENSP00000484620
  • ENSG00000275338
  • ENST00000611004
  • ENSP00000482156

Symbol
  • ARFO1
  • KIAA0665
  • CART1
  • Rab11-FIP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
cellular component
0.76
transcription factor binding site profile
0.75
transcription factor
0.73
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.98   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 86   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.98   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 86   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
73.6
mean platelet volume
2
2
2
73.6
platelet count
2
2
2
68.2
platelet count
2
2
2
68.2
platelet crit
1
1
1
45.6
Items per page:
1 – 5 of 12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
73.6
mean platelet volume
2
73.6
platelet count
2
68.2
platelet count
2
68.2
platelet crit
1
45.6
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Reactome
VxPx cargo-targeting to cilium
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Organelle biogenesis and maintenance
VxPx cargo-targeting to cilium
Gene Ontology Terms (24)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
FlyBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (113)
1 – 10 of 113
RAB11FIP4
Tbio
Novelty: 0.13545871
p_int: 1
Score: 0.916
Data Source: BioPlex,STRINGDB
RAB11A
Tbio
Family: Enzyme
Novelty: 0.00153551
Score: 0.999
Data Source: Reactome,STRINGDB
RAB3IP
Tbio
Novelty: 0.04046982
Score: 0.987
Data Source: Reactome,STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.979
Data Source: STRINGDB
EXOC7
Tbio
Novelty: 0.00852508
Score: 0.971
Data Source: STRINGDB
ARF4
Tbio
Family: Enzyme
Novelty: 0.01166211
Score: 0.97
Data Source: Reactome,STRINGDB
ASAP1
Tbio
Novelty: 0.00913771
Score: 0.965
Data Source: Reactome,STRINGDB
RAB8A
Tbio
Family: Enzyme
Novelty: 0.00486694
Score: 0.947
Data Source: Reactome,STRINGDB
EXOC6
Tbio
Novelty: 0.01886811
Score: 0.94
Data Source: STRINGDB
EXOC5
Tbio
Novelty: 0.02200205
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.98

PubMed score by year
PubTator Score  13.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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