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Tbio
RNF40
E3 ubiquitin-protein ligase BRE1B

Protein Summary
Description
Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324685
  • ENSP00000325677
  • ENSG00000103549
  • ENST00000357890
  • ENSP00000350563

Symbol
  • BRE1B
  • KIAA0661
  • BRE1B
  • RBP95
  • STARING
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
disease perturbation
0.83
biological process
0.73
microRNA
0.67
tissue sample
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.46   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 245   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.46   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 245   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
WAC
Tbio
Novelty:  0.02189388
p_int:  0.99999978
p_ni:  2.2e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999905562
p_ni:  0.000094438
Data Source:  BioPlex
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999862005
p_ni:  0.000137995
Data Source:  BioPlex
IL36A
Tbio
Novelty:  0.03569425
p_int:  0.999802081
p_ni:  0.000197919
Score:  0.207
Data Source:  BioPlex,STRINGDB
DISC1
Tbio
Novelty:  0.00183442
p_int:  0.999755269
p_ni:  0.000244731
Data Source:  BioPlex
OLFM2
Tbio
Novelty:  0.06929963
p_int:  0.99973586
p_ni:  0.00026414
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.998083808
p_ni:  0.001916192
Data Source:  BioPlex
COG6
Tbio
Novelty:  0.02874093
p_int:  0.996712143
p_ni:  0.003287857
Score:  0.203
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.994436027
p_ni:  0.005563973
Data Source:  BioPlex
NUP62
Tbio
Novelty:  0.01432724
p_int:  0.989976525
p_ni:  0.010023475
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
E3 ubiquitin ligases ubiquitinate target proteins (R-HSA-8866654)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
E3 ubiquitin ligases ubiquitinate target proteins
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein ubiquitination
Name
Explore in Pharos
Explore in Source
E3 ubiquitin ligases ubiquitinate target proteins
Metabolism of proteins
Post-translational protein modification
Protein ubiquitination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
1
1
71.3
comparative body size at age 10, self-reported
1
1
1
54.4
HbA1c measurement
1
1
1
52
testosterone measurement
2
2
2
46.5
HMG CoA reductase inhibitor use measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
1
71.3
comparative body size at age 10, self-reported
1
54.4
HbA1c measurement
1
52
testosterone measurement
2
46.5
HMG CoA reductase inhibitor use measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 40
VGNC:9101
454054
Macaque
ring finger protein 40
713148
Mouse
MGI:2142048
233900
Rat
RGD:628638
266712
Dog
ring finger protein 40
VGNC:45669
489913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ring finger protein 40
Macaque
ring finger protein 40
Mouse
Rat
Dog
ring finger protein 40
Publication Statistics
PubMed Score 15.46
PubMed score by year
PubTator Score 14.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title