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Tbio
OBSL1
Obscurin-like protein 1

Protein Summary
Description
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695, PubMed:24793696). Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons. Cytoskeletal adaptor proteins function in linking the internal cytoskeleton of cells to the cell membrane. This gene encodes a cytoskeletal adaptor protein, which is a member of the Unc-89/obscurin family. The protein contains multiple N- and C-terminal immunoglobulin (Ig)-like domains and a central fibronectin type 3 domain. Mutations in this gene cause 3M syndrome type 2. Alternatively spliced transcript variants encoding different isoforms have been found in this gene. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373873
  • ENSP00000362980
  • ENSG00000124006
  • ENST00000404537
  • ENSP00000385636
  • ENST00000603926
  • ENSP00000474519

Symbol
  • KIAA0657
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
protein domain
0.85
PubMedID
0.77
cellular component
0.72
interacting protein
0.68


Related Tools
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.95   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.95   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
obscurin like 1
VGNC:14328
459967
Mouse
MGI:2138628
98733
Rat
RGD:1306073
363259
Cow
obscurin like 1
VGNC:32395
511087
Pig
obscurin like 1
100624019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
obscurin like 1
Mouse
Rat
Cow
obscurin like 1
Pig
obscurin like 1
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75147-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Protein-Protein Interactions (92)
1 – 10 of 92
MISP
Tbio
Novelty: 0.02030151
p_int: 0.99995286
p_ni: 0.00004714
Data Source: BioPlex
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999748395
p_ni: 0.000251605
Score: 0.758
Data Source: BioPlex,STRINGDB
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.999490129
p_ni: 0.000509871
Data Source: BioPlex
PAK5
Tchem
Family: Kinase
Novelty: 0.02138632
p_int: 0.999123518
p_ni: 0.000876482
Data Source: BioPlex
C16orf71
Tdark
Novelty: 0.97826087
p_int: 0.997569817
p_ni: 0.002430183
Data Source: BioPlex
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.995276715
p_ni: 0.004723285
Data Source: BioPlex
ADPRH
Tbio
Family: Enzyme
Novelty: 0.1210664
p_int: 0.992561611
p_ni: 0.007438389
Score: 0.209
Data Source: BioPlex,STRINGDB
NFATC1
Tbio
Family: TF
Novelty: 0.00130337
p_int: 0.984538502
p_ni: 0.015461498
Data Source: BioPlex
ANTXR1
Tbio
Novelty: 0.00508081
p_int: 0.97826208
p_ni: 0.02173792
Score: 0.204
Data Source: BioPlex,STRINGDB
PHF8
Tchem
Family: Epigenetic
Novelty: 0.01946151
p_int: 0.974697554
p_ni: 0.025302446
Data Source: BioPlex
Publication Statistics
PubMed Score  28.95

PubMed score by year
PubTator Score  14.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer