You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HIP1R
Huntingtin-interacting protein 1-related protein

Protein Summary
Description
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253083
  • ENSP00000253083
  • ENSG00000130787

Symbol
  • HIP12
  • KIAA0655
  • HIP3
  • HIP12
  • ILWEQ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
virus perturbation
0.9
cellular component
0.82
interacting protein
0.76
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.71   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 267   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.71   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 267   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
74.8
1
1
0
1.1
25.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
74.8
0
1.1
25.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
huntingtin interacting protein 1 related
VGNC:5416
100613620
Macaque
huntingtin interacting protein 1 related
707396
Mouse
MGI:1352504
29816
Rat
RGD:621615
81917
Dog
huntingtin interacting protein 1 related
VGNC:41692
486251
Species
Name
OMA
EggNOG
Inparanoid
Chimp
huntingtin interacting protein 1 related
Macaque
huntingtin interacting protein 1 related
Mouse
Rat
Dog
huntingtin interacting protein 1 related
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75146-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (50)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (252)
1 – 10 of 252
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999999932
p_ni: 6.8e-8
Score: 0.541
Data Source: BioPlex,STRINGDB
HIP1
Tbio
Novelty: 0.03790722
p_int: 0.999995028
p_ni: 0.000004827
p_wrong: 1.45e-7
Score: 0.937
Data Source: BioPlex,STRINGDB
FAM234B
Tdark
Novelty: 1.53957047
p_int: 0.999828481
p_ni: 0.000171519
Data Source: BioPlex
REPS1
Tbio
Novelty: 0.08952347
p_int: 0.99948059
p_ni: 0.00051941
Score: 0.93
Data Source: BioPlex,STRINGDB
SCN2B
Tbio
Family: IC
Novelty: 0.03773629
p_int: 0.999456885
p_ni: 0.000543115
Data Source: BioPlex
SLC39A9
Tbio
Family: Transporter
Novelty: 0.06143625
p_int: 0.999090415
p_ni: 0.000909585
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.999043934
p_ni: 0.000956066
Data Source: BioPlex
SLC2A9
Tbio
Family: Transporter
Novelty: 0.00683926
p_int: 0.998275075
p_ni: 0.001724923
p_wrong: 2e-9
Data Source: BioPlex
TEX29
Tdark
Novelty: 2.30568043
p_int: 0.997545356
p_ni: 0.002454644
Data Source: BioPlex
SLC22A2
Tchem
Family: Transporter
Novelty: 0.00439263
p_int: 0.99616983
p_ni: 0.003829979
p_wrong: 1.91e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  45.71

PubMed score by year
PubTator Score  58.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer