Tbio ICOSLG ICOS ligand

Protein Summary

Description

Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (By similarity).

Uniprot Accession IDs

• O75144
• A8MUZ1
• Q9HD18
• Q9NRQ1

Gene Name

• ICOSLG

Ensembl ID

• ENST00000344330
• ENSP00000339477
• ENSG00000160223
• ENST00000400377
• ENSP00000383228
• ENST00000407780
• ENSP00000384432

Symbol

• B7H2
• B7RP1
• ICOSL
• KIAA0653

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.63
transcription factor	0.63
small molecule perturbation	0.62
histone modification site profile	0.61
disease	0.57

Protein Classes

PANTHER Classes

Protein / ... / Protease Inhibitor / Icos Ligand

DTO Classes

Protein / Enzyme Modulator / Protease Inhibitor / Icos Ligand

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.68   (req: < 5)

Gene RIFs: 51   (req: <= 3)

Antibodies: 693   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.68   (req: >= 5)

Gene RIFs: 51   (req: > 3)

Antibodies: 693   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0