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Tbio
ATG13
Autophagy-related protein 13

Protein Summary
Description
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359513
  • ENSP00000352500
  • ENSG00000175224
  • ENST00000524625
  • ENSP00000433543
  • ENST00000526508
  • ENSP00000431974
  • ENST00000528494
  • ENSP00000432412
  • ENST00000529655
  • ENSP00000433756
  • ENST00000530500
  • ENSP00000434390

Symbol
  • KIAA0652
  • KIAA0652
  • PARATARG8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.89
kinase perturbation
0.84
transcription factor binding site profile
0.77
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.79   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 534   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.79   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
1
1
33.6
reaction time measurement
1
1
1
32
Headache
1
1
1
26.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
1
33.6
reaction time measurement
1
32
Headache
1
26.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
autophagy related 13
VGNC:3206
451155
Macaque
autophagy related 13
714322
Mouse
MGI:1196429
51897
Rat
RGD:1310685
362164
Dog
autophagy related 13
VGNC:38217
483632
Species
Name
OMA
EggNOG
Inparanoid
Chimp
autophagy related 13
Macaque
autophagy related 13
Mouse
Rat
Dog
autophagy related 13
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75143-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (320)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (120)
1 – 10 of 120
BRK1
Tbio
Novelty: 0.02289534
p_int: 0.999999907
p_ni: 7.8e-8
p_wrong: 1.5e-8
Data Source: BioPlex
ATG101
Tbio
Novelty: 0.03407206
p_int: 0.99999987
p_ni: 1.9e-8
p_wrong: 1.11e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
WASHC3
Tdark
Novelty: 0.18307321
p_int: 0.999996312
p_ni: 0.000003687
p_wrong: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
FAM221B
Tdark
Novelty: 71
p_int: 0.999994961
p_ni: 0.000005033
p_wrong: 6e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
DENR
Tbio
Novelty: 0.00653432
p_int: 0.999773282
p_ni: 0.000140884
p_wrong: 0.000085834
Score: 0.189
Data Source: BioPlex,STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00240301
Score: 0.999
Data Source: Reactome,STRINGDB
RB1CC1
Tbio
Novelty: 0.00744817
Score: 0.999
Data Source: Reactome,STRINGDB
ULK2
Tchem
Family: Kinase
Novelty: 0.02285321
Score: 0.992
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.0003792
Score: 0.991
Data Source: Reactome,STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00269825
Score: 0.991
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  93.79

PubMed score by year
PubTator Score  30.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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