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Tbio
ATG13
Autophagy-related protein 13

Protein Summary
Description
Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. The protein encoded by this gene is an autophagy factor and a target of the TOR kinase signaling pathway. The encoded protein is essential for autophagosome formation and mitophagy. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359513
  • ENSP00000352500
  • ENSG00000175224
  • ENST00000524625
  • ENSP00000433543
  • ENST00000526508
  • ENSP00000431974
  • ENST00000528494
  • ENSP00000432412
  • ENST00000529655
  • ENSP00000433756
  • ENST00000530500
  • ENSP00000434390

Symbol
  • KIAA0652
  • KIAA0652
  • PARATARG8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.89
kinase perturbation
0.84
transcription factor binding site profile
0.77
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.91   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 534   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.91   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 534   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (320)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (120)
1 – 10 of 120
BRK1
Tbio
Novelty: 0.03479369
p_int: 0.999999907
p_ni: 7.8e-8
p_wrong: 1.5e-8
Data Source: BioPlex
ATG101
Tbio
Novelty: 0.07411874
p_int: 0.99999987
p_ni: 1.9e-8
p_wrong: 1.11e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
WASHC3
Tdark
Novelty: 0.37393768
p_int: 0.999996312
p_ni: 0.000003687
p_wrong: 1e-9
Score: 0.165
Data Source: BioPlex,STRINGDB
FAM221B
Tdark
p_int: 0.999994961
p_ni: 0.000005033
p_wrong: 6e-9
Score: 0.29
Data Source: BioPlex,STRINGDB
DENR
Tbio
Novelty: 0.00702179
p_int: 0.999773282
p_ni: 0.000140884
p_wrong: 0.000085834
Score: 0.189
Data Source: BioPlex,STRINGDB
ULK1
Tchem
Family: Kinase
Novelty: 0.00384751
Score: 0.999
Data Source: Reactome,STRINGDB
RB1CC1
Tbio
Novelty: 0.01137369
Score: 0.999
Data Source: Reactome,STRINGDB
ULK2
Tchem
Family: Kinase
Novelty: 0.04628321
Score: 0.992
Data Source: STRINGDB
BECN1
Tbio
Novelty: 0.00046615
Score: 0.991
Data Source: Reactome,STRINGDB
PIK3C3
Tchem
Family: Kinase
Novelty: 0.00398886
Score: 0.991
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  39.91

PubMed score by year
PubTator Score  30.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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