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Tbio
DEPDC5
GATOR complex protein DEPDC5

Protein Summary
Description
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382111
  • ENSP00000371545
  • ENSG00000100150
  • ENST00000382112
  • ENSP00000371546
  • ENST00000400242
  • ENSP00000383101
  • ENST00000400246
  • ENSP00000383105
  • ENST00000400248
  • ENSP00000383107
  • ENST00000400249
  • ENSP00000383108
  • ENST00000535622
  • ENSP00000440210
  • ENST00000642696
  • ENSP00000495917
  • ENST00000644331
  • ENSP00000494406
  • ENST00000645711
  • ENSP00000493489
  • ENST00000646755
  • ENSP00000496532

Symbol
  • KIAA0645
  • DEP.5
  • FFEVF
  • FFEVF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
kinase perturbation
0.81
transcription factor
0.78
histone modification site profile
0.77
cell line
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.92   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.92   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0