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Tbio
DEPDC5
GATOR complex protein DEPDC5

Protein Summary
Description
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382111
  • ENSP00000371545
  • ENSG00000100150
  • ENST00000382112
  • ENSP00000371546
  • ENST00000400242
  • ENSP00000383101
  • ENST00000400246
  • ENSP00000383105
  • ENST00000400248
  • ENSP00000383107
  • ENST00000400249
  • ENSP00000383108
  • ENST00000535622
  • ENSP00000440210
  • ENST00000642696
  • ENSP00000495917
  • ENST00000644331
  • ENSP00000494406
  • ENST00000645711
  • ENSP00000493489
  • ENST00000646755
  • ENSP00000496532

Symbol
  • KIAA0645
  • DEP.5
  • FFEVF
  • FFEVF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
kinase perturbation
0.81
transcription factor
0.78
histone modification site profile
0.77
cell line
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.72   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.72   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronic hepatitis C virus infection
1
1
0
1.8
87.2
mathematical ability
2
2
2
69.3
Cleft palate
1
1
0
1.3
39.6
1
1
0
1.3
39.6
1
1
1
37.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronic hepatitis C virus infection
0
1.8
87.2
mathematical ability
2
69.3
Cleft palate
0
1.3
39.6
0
1.3
39.6
1
37.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DEP domain containing 5
VGNC:5252
107970229
Mouse
MGI:2141101
277854
Rat
RGD:1311535
305464
Dog
DEP domain containing 5
VGNC:39898
477546
Horse
DEP domain containing 5
VGNC:17133
100058243
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DEP domain containing 5
Mouse
Rat
Dog
DEP domain containing 5
Horse
DEP domain containing 5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75140-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (78)
1 – 10 of 78
NPRL2
Tbio
Family: Enzyme
Novelty: 0.02848752
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BMT2
Tbio
Family: Enzyme
Novelty: 0.05916379
p_int: 0.999999999
p_ni: 1e-9
Score: 0.867
Data Source: BioPlex,Reactome,STRINGDB
SZT2
Tbio
Novelty: 0.06995258
p_int: 0.999958755
p_ni: 0.000041245
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
LMO1
Tbio
Novelty: 0.01670419
p_int: 0.997058783
p_ni: 0.002937412
p_wrong: 0.000003805
Data Source: BioPlex
C12orf66
Tbio
Novelty: 1.38775963
p_int: 0.996837934
p_ni: 0.000282394
p_wrong: 0.002879672
Score: 0.95
Data Source: BioPlex,Reactome,STRINGDB
ITFG2
Tbio
Novelty: 0.41720651
p_int: 0.980599279
p_ni: 0.01940072
Score: 0.921
Data Source: BioPlex,Reactome,STRINGDB
KPTN
Tbio
Novelty: 0.06841936
p_int: 0.797858194
p_ni: 0.202141806
Score: 0.9
Data Source: BioPlex,Reactome,STRINGDB
WDR24
Tdark
Novelty: 0.48411996
Score: 0.999
Data Source: STRINGDB
RRAGA
Tbio
Novelty: 0.02022668
Score: 0.999
Data Source: STRINGDB
MIOS
Tdark
Novelty: 0.04252507
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.72

PubMed score by year
PubTator Score  42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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