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Tbio
COBL
Protein cordon-bleu

Protein Summary
Description
Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles. This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265136
  • ENSP00000265136
  • ENSG00000106078
  • ENST00000395540
  • ENSP00000378910
  • ENST00000395542
  • ENSP00000378912
  • ENST00000441453
  • ENSP00000399500

Symbol
  • KIAA0633
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
cellular component
0.79
PubMedID
0.78
transcription factor perturbation
0.74
transcription factor binding site profile
0.7


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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.98   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.98   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cordon-bleu WH2 repeat protein
VGNC:4313
463412
Macaque
cordon-bleu WH2 repeat protein
693867
Mouse
MGI:105056
12808
Rat
RGD:1312002
305497
Dog
cordon-bleu WH2 repeat protein
VGNC:39445
607873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cordon-bleu WH2 repeat protein
Macaque
cordon-bleu WH2 repeat protein
Mouse
Rat
Dog
cordon-bleu WH2 repeat protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75128-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (24)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (52)
1 – 10 of 52
PACSIN2
Tbio
Family: Enzyme
Novelty: 0.0250489
p_int: 1
Score: 0.908
Data Source: BioPlex,STRINGDB
POTEKP
Tdark
p_int: 0.999999998
p_ni: 1e-9
p_wrong: 1e-9
Data Source: BioPlex
PACSIN3
Tbio
Family: Enzyme
Novelty: 0.11715903
p_int: 0.999999773
p_ni: 2.27e-7
Score: 0.876
Data Source: BioPlex,STRINGDB
PACSIN1
Tbio
Family: Enzyme
Novelty: 0.01482925
p_int: 0.999999729
p_ni: 2.69e-7
p_wrong: 2e-9
Score: 0.929
Data Source: BioPlex,STRINGDB
FHL3
Tbio
Novelty: 0.11505924
p_int: 0.999999494
p_ni: 5.06e-7
Data Source: BioPlex
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.998189723
p_ni: 0.001810277
Data Source: BioPlex
WDR47
Tdark
Novelty: 0.51632776
p_int: 0.997061485
p_ni: 0.002938286
p_wrong: 2.29e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
TMOD3
Tbio
Novelty: 0.04744699
p_int: 0.995887837
p_ni: 0.004112152
p_wrong: 1.1e-8
Score: 0.69
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.988419636
p_ni: 0.011580365
Score: 0.156
Data Source: BioPlex,STRINGDB
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.89576892
p_ni: 0.10423108
Data Source: BioPlex
Publication Statistics
PubMed Score  55.98

PubMed score by year
PubTator Score  15.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer