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Tbio
CLASP2
CLIP-associating protein 2

Protein Summary
Description
Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313350
  • ENSP00000324364
  • ENSG00000163539
  • ENST00000359576
  • ENSP00000352581

Symbol
  • KIAA0627
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
ligand (protein) perturbation
0.96
interacting protein
0.95
virus perturbation
0.94
cellular component
0.81


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.06   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytoplasmic linker associated protein 2
VGNC:1778
460258
Mouse
MGI:1923749
76499
Rat
RGD:619789
114514
Dog
cytoplasmic linker associated protein 2
VGNC:39295
477012
Horse
cytoplasmic linker associated protein 2
VGNC:16568
100055883
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytoplasmic linker associated protein 2
Mouse
Rat
Dog
cytoplasmic linker associated protein 2
Horse
cytoplasmic linker associated protein 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75122-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Axon guidance
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Axon guidance
Cell Cycle
Cell Cycle Checkpoints
Gene Ontology Terms (49)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (166)
1 – 10 of 166
MAPRE1
Tbio
Novelty: 0.01267772
p_int: 0.999997957
p_ni: 0.000002043
Score: 0.965
Data Source: BioPlex,STRINGDB
KLHDC3
Tdark
Novelty: 0.63840156
p_int: 0.999015488
p_ni: 0.00098063
p_wrong: 0.000003883
Data Source: BioPlex
FAM43A
Tdark
Novelty: 1.17401589
p_int: 0.997388565
p_ni: 0.002607536
p_wrong: 0.000003899
Score: 0.243
Data Source: BioPlex,STRINGDB
CSGALNACT2
Tbio
Family: Enzyme
Novelty: 0.0770692
p_int: 0.997318542
p_ni: 0.002680048
p_wrong: 0.00000141
Data Source: BioPlex
LYPD3
Tbio
Novelty: 0.03248533
p_int: 0.996801569
p_ni: 0.003195613
p_wrong: 0.000002818
Data Source: BioPlex
GORASP1
Tbio
Novelty: 0.02332405
p_int: 0.996175497
p_ni: 0.003820207
p_wrong: 0.000004296
Score: 0.327
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.995101597
p_ni: 0.004897818
p_wrong: 5.86e-7
Data Source: BioPlex
ID2
Tbio
Family: TF
Novelty: 0.00256364
p_int: 0.994144077
p_ni: 0.004588968
p_wrong: 0.001266954
Score: 0.181
Data Source: BioPlex,STRINGDB
CLIP1
Tbio
Novelty: 0.00399891
Score: 0.99
Data Source: STRINGDB
CKAP5
Tbio
Novelty: 0.00623771
Score: 0.983
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.06

PubMed score by year
PubTator Score  23.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer