Tbio N4BP1 NEDD4-binding protein 1

Protein Summary

Description

Inhibitor of the E3 ubiquitin-protein ligase ITCH. Acts by interacting with the second WW domain of ITCH, leading to compete with ITCH's substrates and impairing ubiquitination of substrates (By similarity).

Uniprot Accession IDs

• O75113
• A7MD49
• Q2YDX1
• N4BP1

Gene Name

• N4BP1

Ensembl ID

• ENST00000262384
• ENSP00000262384
• ENSG00000102921

Symbol

• KIAA0615

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
disease perturbation	0.9
transcription factor binding site profile	0.81
microRNA	0.72
cell line	0.66

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nedd4-binding Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Nedd4-binding Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0