LDB3
LIM domain-binding protein 3
Protein Summary
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-term ...more
- ENST00000263066
- ENSP00000263066
- ENSG00000122367
- ENST00000361373
- ENSP00000355296
- ENST00000372056
- ENSP00000361126
- ENST00000372066
- ENSP00000361136
- ENST00000429277
- ENSP00000401437
- ENST00000623007
- ENSP00000485389
- ENST00000623056
- ENSP00000485500
- KIAA0613
- ZASP
- MFM4
- ZASP
- CMD1C
- CMH24
- CMPD3
- LVNC3
- CYPHER
- LDB3Z1
- LDB3Z4
- ORACLE
- PDLIM6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.91 | ||
microRNA | 0.82 | ||
disease perturbation | 0.62 | ||
phenotype | 0.62 | ||
transcription factor perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.61 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 237 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.61 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 237 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (148)
HSPA1A
Novelty: 0.00069195
p_int: 0.999961257
p_ni: 0.000038743
Score: 0.528
Data Source: BioPlex,STRINGDB
NPC2
Novelty: 0.00342898
p_int: 0.891871123
p_ni: 0.077813582
p_wrong: 0.030315295
Score: 0.494
Data Source: BioPlex,STRINGDB
RSPH6A
Novelty: 0.03734897
p_int: 0.885946137
p_ni: 2.5e-8
p_wrong: 0.114053838
Data Source: BioPlex
RHOA
Family: Enzyme
Novelty: 0.00022204
p_int: 0.8761198
p_ni: 0.10842165
p_wrong: 0.01545855
Score: 0.402
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (4)
Components (4)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 1 | 1 | 33.1 | |||||
BMI-adjusted waist circumference | 1 | 1 | 1 | 27.3 | |||||
electrocardiography | 1 | 1 | 2 | 15.8 | |||||
apolipoprotein A 1 measurement | 1 | 1 | 1 | 6.1 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 1.7 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 33.1 | |||||
BMI-adjusted waist circumference | 1 | 27.3 | |||||
electrocardiography | 2 | 15.8 | |||||
apolipoprotein A 1 measurement | 1 | 6.1 | |||||
high density lipoprotein cholesterol measurement | 1 | 1.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LIM domain binding 3 | VGNC:12360 | 735476 | |||||
Macaque | LIM domain binding 3 | 697140 | ||||||
Mouse | MGI:1344412 | 24131 | ||||||
Dog | LIM domain binding 3 | VGNC:42620 | 479269 | |||||
Horse | LIM domain binding 3 | VGNC:51551 | 100052406 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LIM domain binding 3 | |||||
Macaque | LIM domain binding 3 | |||||
Mouse | ||||||
Dog | LIM domain binding 3 | |||||
Horse | LIM domain binding 3 | |||||
Publication Statistics
PubMed Score 83.61
PubMed score by year
PubTator Score 266.93
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (17)
Items per page:
0 of 0
PMID | Year | Title |
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