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Tbio
LDB3
LIM domain-binding protein 3

Protein Summary
Description
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-term ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263066
  • ENSP00000263066
  • ENSG00000122367
  • ENST00000361373
  • ENSP00000355296
  • ENST00000372056
  • ENSP00000361126
  • ENST00000372066
  • ENSP00000361136
  • ENST00000429277
  • ENSP00000401437
  • ENST00000623007
  • ENSP00000485389
  • ENST00000623056
  • ENSP00000485500

Symbol
  • KIAA0613
  • ZASP
  • MFM4
  • ZASP
  • CMD1C
  • CMH24
  • CMPD3
  • LVNC3
  • CYPHER
  • LDB3Z1
  • LDB3Z4
  • ORACLE
  • PDLIM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
microRNA
0.82
disease perturbation
0.62
phenotype
0.62
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.61   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (148)
HSPA1A
Tchem
Novelty:  0.00069195
p_int:  0.999961257
p_ni:  0.000038743
Score:  0.528
Data Source:  BioPlex,STRINGDB
NPC2
Tbio
Novelty:  0.00342898
p_int:  0.891871123
p_ni:  0.077813582
p_wrong:  0.030315295
Score:  0.494
Data Source:  BioPlex,STRINGDB
RSPH6A
Tdark
Novelty:  0.03734897
p_int:  0.885946137
p_ni:  2.5e-8
p_wrong:  0.114053838
Data Source:  BioPlex
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.8761198
p_ni:  0.10842165
p_wrong:  0.01545855
Score:  0.402
Data Source:  BioPlex,STRINGDB
ACTN2
Tbio
Novelty:  0.00615882
Score:  0.983
Data Source:  STRINGDB
MYOZ2
Tbio
Novelty:  0.04557513
Score:  0.963
Data Source:  STRINGDB
TTN
Tbio
Family:  Kinase
Novelty:  0.00040356
Score:  0.927
Data Source:  STRINGDB
ACTN1
Tbio
Novelty:  0.00654004
Score:  0.887
Data Source:  STRINGDB
ACTN3
Tbio
Novelty:  0.00375035
Score:  0.874
Data Source:  STRINGDB
MYOZ3
Tdark
Novelty:  0.23814262
Score:  0.872
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
33.1
BMI-adjusted waist circumference
1
1
1
27.3
electrocardiography
1
1
2
15.8
apolipoprotein A 1 measurement
1
1
1
6.1
high density lipoprotein cholesterol measurement
1
1
1
1.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
33.1
BMI-adjusted waist circumference
1
27.3
electrocardiography
2
15.8
apolipoprotein A 1 measurement
1
6.1
high density lipoprotein cholesterol measurement
1
1.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain binding 3
VGNC:12360
735476
Macaque
LIM domain binding 3
697140
Mouse
MGI:1344412
24131
Dog
LIM domain binding 3
VGNC:42620
479269
Horse
LIM domain binding 3
VGNC:51551
100052406
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain binding 3
Macaque
LIM domain binding 3
Mouse
Dog
LIM domain binding 3
Horse
LIM domain binding 3
Publication Statistics
PubMed Score 83.61
PubMed score by year
PubTator Score 266.93
PubTator score by year
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Related Publications
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PMID
Year
Title