Tchem FZD7 Frizzled-7

Protein Summary

Description

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75084
• O94816
• Q53S59
• Q96B74
• Fz-7

Gene Name

• FZD7

Ensembl ID

• ENST00000286201
• ENSP00000286201
• ENSG00000155760

Symbol

• FzE3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
biological process	0.96
transcription factor perturbation	0.94
kinase perturbation	0.93
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-7

Protein / Receptor / G-protein Coupled Receptor / Frizzled-7

Protein / ... / Protease Inhibitor / Frizzled-7

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.09   (req: < 5)

Gene RIFs: 60   (req: <= 3)

Antibodies: 464   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.09   (req: >= 5)

Gene RIFs: 60   (req: > 3)

Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0