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Tbio
FZD7
Frizzled-7

Protein Summary
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286201
  • ENSP00000286201
  • ENSG00000155760

Symbol
  • FzE3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
biological process
0.96
transcription factor perturbation
0.94
kinase perturbation
0.93
transcription factor binding site profile
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.27   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 464   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.27   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:108570
14369
Rat
RGD:2321905
100360552
Cow
frizzled class receptor 7
VGNC:29171
524255
Pig
frizzled class receptor 7
100513691
Opossum
frizzled class receptor 7
100019281
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
frizzled class receptor 7
Pig
frizzled class receptor 7
Opossum
frizzled class receptor 7
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75084-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (115)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
PCP/CE pathway
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Class B/2 (Secretin family receptors)
GPCR ligand binding
PCP/CE pathway
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
WormBase
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
LAMP1
Tbio
Novelty: 0.00067563
p_int: 0.999916751
p_ni: 0.000083249
Score: 0.165
Data Source: BioPlex,STRINGDB
UPK1A
Tbio
Novelty: 0.01748122
p_int: 0.999862023
p_ni: 0.000136311
p_wrong: 0.000001666
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.998726911
p_ni: 0.000154963
p_wrong: 0.001118126
Data Source: BioPlex
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.998379674
p_ni: 0.000322541
p_wrong: 0.001297785
Data Source: BioPlex
VNN2
Tbio
Novelty: 0.02286648
p_int: 0.995173347
p_ni: 0.000267296
p_wrong: 0.004559357
Data Source: BioPlex
ZACN
Tchem
Family: IC
Novelty: 0.21891621
p_int: 0.99511971
p_ni: 0.000386472
p_wrong: 0.004493819
Data Source: BioPlex
OR13J1
Tdark
Family: oGPCR
Novelty: 2.15311005
p_int: 0.780976579
p_ni: 0.055199629
p_wrong: 0.163823792
Data Source: BioPlex
WNT11
Tbio
Novelty: 0.0045754
Score: 0.986
Data Source: Reactome,STRINGDB
WNT3
Tchem
Novelty: 0.00498299
Score: 0.983
Data Source: STRINGDB
WNT5A
Tbio
Novelty: 0.00125563
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  118.27

PubMed score by year
PubTator Score  67.43

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer