Protein Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich e ...more
- ENST00000286201
- ENSP00000286201
- ENSG00000155760
- FzE3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
PubMedID | 0.98 | ||
biological process | 0.96 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
transcription factor binding site profile | 0.87 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.15 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 464 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.15 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 464 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 33
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (33)
Protein-Protein Interactions (122)
LAMP1
Novelty: 0.00067563
p_int: 0.999916751
p_ni: 0.000083249
Score: 0.165
Data Source: BioPlex,STRINGDB
UPK1A
Novelty: 0.01748122
p_int: 0.999862023
p_ni: 0.000136311
p_wrong: 0.000001666
Data Source: BioPlex
SLC39A4
Family: Transporter
Novelty: 0.00742159
p_int: 0.998726911
p_ni: 0.000154963
p_wrong: 0.001118126
Data Source: BioPlex
ATP2B2
Family: Transporter
Novelty: 0.007782
p_int: 0.998379674
p_ni: 0.000322541
p_wrong: 0.001297785
Data Source: BioPlex
VNN2
Novelty: 0.02286648
p_int: 0.995173347
p_ni: 0.000267296
p_wrong: 0.004559357
Data Source: BioPlex
ZACN
Family: IC
Novelty: 0.21891621
p_int: 0.99511971
p_ni: 0.000386472
p_wrong: 0.004493819
Data Source: BioPlex
OR13J1
Family: oGPCR
Novelty: 2.15311005
p_int: 0.780976579
p_ni: 0.055199629
p_wrong: 0.163823792
Data Source: BioPlex
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (115)
Reactome (8)
KEGG (13)
PathwayCommons (32)
WikiPathways (62)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Reactome | PCP/CE pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
PCP/CE pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (6)
Components (3)
Processes (21)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | WormBase | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 5 | 13 | 98.5 | |||||
balding measurement | 1 | 1 | 1 | 79.6 | |||||
bone density | 1 | 2 | 2 | 61.3 | |||||
vital capacity | 1 | 1 | 1 | 56 | |||||
self reported educational attainment | 2 | 2 | 2 | 51.7 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 13 | 98.5 | |||||
balding measurement | 1 | 79.6 | |||||
bone density | 2 | 61.3 | |||||
vital capacity | 1 | 56 | |||||
self reported educational attainment | 2 | 51.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Mouse | MGI:108570 | 14369 | ||||||
Rat | RGD:2321905 | 100360552 | ||||||
Cow | frizzled class receptor 7 | VGNC:29171 | 524255 | |||||
Pig | frizzled class receptor 7 | 100513691 | ||||||
Opossum | frizzled class receptor 7 | 100019281 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Cow | frizzled class receptor 7 | |||||
Pig | frizzled class receptor 7 | |||||
Opossum | frizzled class receptor 7 | |||||
Publication Statistics
PubMed Score 123.15
PubMed score by year
PubTator Score 67.43
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (70)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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