Tbio FZD7 Frizzled-7

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-7

Protein / Receptor / G-protein Coupled Receptor / Frizzled-7

Protein / ... / Protease Inhibitor / Frizzled-7

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-7

Protein Summary

Description

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75084
• O94816
• Q53S59
• Q96B74
• Fz-7

Gene Name

• FZD7

Ensembl ID

• ENST00000286201
• ENSP00000286201
• ENSG00000155760

Symbol

• FzE3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
biological process	0.96
transcription factor perturbation	0.94
kinase perturbation	0.93
transcription factor binding site profile	0.87

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.27   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 464   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.27   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	frizzled class receptor 7	MGI:108570	14369
Rat	frizzled class receptor 7	RGD:2321905	100360552
Cow	frizzled class receptor 7	VGNC:29171	524255
Pig	frizzled class receptor 7		100513691
Opossum	frizzled class receptor 7		100019281

Species	Name	OMA	EggNOG	Inparanoid
Mouse	frizzled class receptor 7
Rat	frizzled class receptor 7
Cow	frizzled class receptor 7
Pig	frizzled class receptor 7
Opossum	frizzled class receptor 7

Protein Structure (4 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75084-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (115)

Reactome (8)

KEGG (13)

PathwayCommons (32)

WikiPathways (62)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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Find Similar Targets

Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
PCP/CE pathway	93 targets	R-HSA-4086400

Gene Ontology Terms (30)

Functions (6)

Components (3)

Processes (21)

Find Similar Targets

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
Wnt-activated receptor activity	Inferred from Direct Assay (IDA)	WormBase
frizzled binding	Inferred from Physical Interaction (IPI)	UniProtKB
PDZ domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
Wnt-protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (122)

Explore Interacting Targets

1 – 10 of 122

• See Interactions on String-DB

LAMP1

Tbio

Novelty: 0.00067563

p_int: 0.999916751

p_ni: 0.000083249

Score: 0.165

Data Source: BioPlex,STRINGDB

UPK1A

Tbio

Novelty: 0.01748122

p_int: 0.999862023

p_ni: 0.000136311

p_wrong: 0.000001666

Data Source: BioPlex

SLC39A4

Tbio

Family: Transporter

Novelty: 0.00742159

p_int: 0.998726911

p_ni: 0.000154963

p_wrong: 0.001118126

Data Source: BioPlex

ATP2B2

Tbio

Family: Transporter

Novelty: 0.007782

p_int: 0.998379674

p_ni: 0.000322541

p_wrong: 0.001297785

Data Source: BioPlex

VNN2

Tbio

Novelty: 0.02286648

p_int: 0.995173347

p_ni: 0.000267296

p_wrong: 0.004559357

Data Source: BioPlex

ZACN

Tchem

Family: IC

Novelty: 0.21891621

p_int: 0.99511971

p_ni: 0.000386472

p_wrong: 0.004493819

Data Source: BioPlex

OR13J1

Tdark

Family: oGPCR

Novelty: 2.15311005

p_int: 0.780976579

p_ni: 0.055199629

p_wrong: 0.163823792

Data Source: BioPlex

WNT11

Tbio

Novelty: 0.0045754

Score: 0.986

Data Source: Reactome,STRINGDB

WNT3

Tchem

Novelty: 0.00498299

Score: 0.983

Data Source: STRINGDB

WNT5A

Tbio

Novelty: 0.00125563

Score: 0.98

Data Source: STRINGDB

Publication Statistics

PubMed Score  118.27

PubMed score by year

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PubTator Score  67.43

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Cell membrane
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G-protein coupled receptor
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cardiovascular system phenotype
limbs/digits/tail phenotype