Tchem FZD7 Frizzled-7

Protein Summary

Description

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75084
• O94816
• Q53S59
• Q96B74
• Fz-7

Gene Name

• FZD7

Ensembl ID

• ENST00000286201
• ENSP00000286201
• ENSG00000155760

Symbol

• FzE3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.98
biological process	0.96
transcription factor perturbation	0.94
kinase perturbation	0.93
transcription factor binding site profile	0.87

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-7

Protein / Receptor / G-protein Coupled Receptor / Frizzled-7

Protein / ... / Protease Inhibitor / Frizzled-7

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.15   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 464   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.15   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 464   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 33

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (33)

Explore Active Ligands

1 – 10 of 33

CHEMBL4557583

FZD7Tchem GPCR

pKd : 9.47

CHEMBL4445160

FZD7Tchem GPCR

pKd : 8.95

CHEMBL4554351

FZD7Tchem GPCR

pKd : 8.62

CHEMBL4450933

FZD7Tchem GPCR

pKd : 10.41

CHEMBL4438919

FZD7Tchem GPCR

pKd : 10.36

CHEMBL4435748

FZD7Tchem GPCR

pKd : 10.35

CHEMBL4514839

FZD7Tchem GPCR

pKd : 10.1

CHEMBL4444797

FZD7Tchem GPCR

pKd : 10.08

CHEMBL4567235

FZD7Tchem GPCR

pKd : 10

CHEMBL4452638

FZD7Tchem GPCR

pKd : 9.85

Protein-Protein Interactions (122)

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1 – 10 of 122

• See Interactions on String-DB

LAMP1

Tbio

Novelty:  0.00067563

p_int:  0.999916751

p_ni:  0.000083249

Score:  0.165

Data Source:  BioPlex,STRINGDB

UPK1A

Tbio

Novelty:  0.01748122

p_int:  0.999862023

p_ni:  0.000136311

p_wrong:  0.000001666

Data Source:  BioPlex

SLC39A4

Tbio

Family:  Transporter

Novelty:  0.00742159

p_int:  0.998726911

p_ni:  0.000154963

p_wrong:  0.001118126

Data Source:  BioPlex

ATP2B2

Tbio

Family:  Transporter

Novelty:  0.007782

p_int:  0.998379674

p_ni:  0.000322541

p_wrong:  0.001297785

Data Source:  BioPlex

VNN2

Tbio

Novelty:  0.02286648

p_int:  0.995173347

p_ni:  0.000267296

p_wrong:  0.004559357

Data Source:  BioPlex

ZACN

Tchem

Family:  IC

Novelty:  0.21891621

p_int:  0.99511971

p_ni:  0.000386472

p_wrong:  0.004493819

Data Source:  BioPlex

OR13J1

Tdark

Family:  oGPCR

Novelty:  2.15311005

p_int:  0.780976579

p_ni:  0.055199629

p_wrong:  0.163823792

Data Source:  BioPlex

WNT11

Tbio

Novelty:  0.0045754

Score:  0.986

Data Source:  Reactome,STRINGDB

WNT3

Tchem

Novelty:  0.00498299

Score:  0.983

Data Source:  STRINGDB

WNT5A

Tbio

Novelty:  0.00125563

Score:  0.98

Data Source:  STRINGDB

Nearest Tclin Targets (9)

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Upstream (7)

Downstream (2)

1 – 5 of 7

EGFR

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: Cushing syndrome

3: Breast cancer

4: Hepatocellular carcinoma

more:  3 more common pathways

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

RAF1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  9

1: Gastric cancer

2: mTOR signaling pathway

3: Breast cancer

4: Signaling pathways regulating pluripotency of stem cells

more:  5 more common pathways

BRAF

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  3 more common pathways

Pathways (115)

Reactome (8)

KEGG (13)

PathwayCommons (32)

WikiPathways (62)

Asymmetric localization of PCP proteins (R-HSA-4608870)

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1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	PCP/CE pathway	93 targets	R-HSA-4086400

Name	Explore in Pharos	Explore in Source
Asymmetric localization of PCP proteins	65 targets	R-HSA-4608870
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
GPCR ligand binding	460 targets	R-HSA-500792
PCP/CE pathway	93 targets	R-HSA-4086400

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (30)

Functions (6)

Components (3)

Processes (21)

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10

1 – 6 of 6

GO Term	Evidence	Assigned by
phosphatidylinositol-4,5-bisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
Wnt-activated receptor activity	Inferred from Direct Assay (IDA)	WormBase
frizzled binding	Inferred from Physical Interaction (IPI)	UniProtKB
PDZ domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
Wnt-protein binding	Inferred from Physical Interaction (IPI)	BHF-UCL
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (13)

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5

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	5	13		98.5
balding measurement	EFO_0007825	1	1	1		79.6
bone density	EFO_0003923	1	2	2		61.3
vital capacity	EFO_0004312	1	1	1		56
self reported educational attainment	EFO_0004784	2	2	2		51.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	13		98.5
balding measurement	EFO_0007825	1		79.6
bone density	EFO_0003923	2		61.3
vital capacity	EFO_0004312	1		56
self reported educational attainment	EFO_0004784	2		51.7

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UniProt Keyword Find Similar Targets

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3D-structure
Cell membrane
Complete proteome
Developmental protein
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Membrane
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
age at first sexual intercourse measurement
alcohol consumption measurement
balding measurement
bone density
C-reactive protein measurement
hair color
heel bone mineral density
neuroticism measurement
risk-taking behaviour
self reported educational attainment

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
limbs/digits/tail phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	frizzled class receptor 7	MGI:108570	14369
Rat	frizzled class receptor 7	RGD:2321905	100360552
Cow	frizzled class receptor 7	VGNC:29171	524255
Pig	frizzled class receptor 7		100513691
Opossum	frizzled class receptor 7		100019281

Species	Name	OMA	EggNOG	Inparanoid
Mouse	frizzled class receptor 7
Rat	frizzled class receptor 7
Cow	frizzled class receptor 7
Pig	frizzled class receptor 7
Opossum	frizzled class receptor 7

Publication Statistics

PubMed Score 123.15

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PubTator Score 67.43

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Related Publications

Text Mined References (70)

GeneRif Annotations (42)

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PMID	Year	Title