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Tbio
WDR1
WD repeat-containing protein 1

Protein Summary
Description
Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins (PubMed:15629458). Enhances cofilin-mediated actin severing (By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions (PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance (By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity (PCP) during follicular epithelium development and for cell shape changes during PCP; the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension (By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt (PubMed:25792565). This gene encodes a protein containing 9 WD repeats. WD repeats are approx ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382451
  • ENSP00000371889
  • ENSG00000071127
  • ENST00000382452
  • ENSP00000371890
  • ENST00000499869
  • ENSP00000427687
  • ENST00000502702
  • ENSP00000426725

Symbol
  • AIP1
  • NORI-1
  • HEL-S-52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.98
transcription factor perturbation
0.98
virus perturbation
0.95
transcription factor binding site profile
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.48   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.48   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
61.6
pulse pressure measurement
1
1
1
40.3
glomerular filtration rate
1
1
1
29.4
serum metabolite measurement
1
1
1
24.7
urate measurement
1
1
1
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
61.6
pulse pressure measurement
1
40.3
glomerular filtration rate
1
29.4
serum metabolite measurement
1
24.7
urate measurement
1
5.2
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 1
VGNC:709
744395
Macaque
WD repeat domain 1
712989
Mouse
MGI:1337100
22388
Rat
RGD:1305789
360950
Dog
WD repeat domain 1
VGNC:48349
611070
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat domain 1
Macaque
WD repeat domain 1
Mouse
Rat
Dog
WD repeat domain 1
Pathways (23)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (30)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (131)
1 – 10 of 131
POTEE
Tbio
Novelty: 0.29349205
p_int: 0.999964751
p_ni: 0.000034806
p_wrong: 4.44e-7
Score: 0.604
Data Source: BioPlex,STRINGDB
ATRX
Tbio
Novelty: 0.00114798
p_int: 0.999181148
p_ni: 0.000573845
p_wrong: 0.000245007
Score: 0.685
Data Source: BioPlex,STRINGDB
CFL1
Tbio
Novelty: 0.00071544
Score: 0.949
Data Source: STRINGDB
UBE2K
Tbio
Novelty: 0.00214955
Score: 0.939
Data Source: STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
Score: 0.895
Data Source: STRINGDB
DSTN
Tbio
Novelty: 0.0130214
Score: 0.872
Data Source: STRINGDB
GGCT
Tchem
Family: Enzyme
Novelty: 0.01154389
Score: 0.866
Data Source: STRINGDB
CFL2
Tbio
Novelty: 0.01563343
Score: 0.843
Data Source: STRINGDB
TYMS
Tclin
Family: Enzyme
Novelty: 0.00087522
Score: 0.824
Data Source: STRINGDB
PPIH
Tbio
Family: Enzyme
Novelty: 0.03225561
Score: 0.818
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.48

PubMed score by year
PubTator Score  30.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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