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Tbio
ADAM11
Disintegrin and metalloproteinase domain-containing protein 11

Protein Classes
Protein Summary
Description
Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000200557
  • ENSP00000200557
  • ENSG00000073670

Symbol
  • MDC
  • MDC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.7
tissue sample
0.53
transcription factor
0.52
histone modification site profile
0.51


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.83   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
LGI-ADAM interactions
Name
Explore in Pharos
Explore in Source
Developmental Biology
LGI-ADAM interactions
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (37)
1 – 10 of 37
TAZ
Tbio
Novelty: 0.00236739
p_int: 0.999267648
p_ni: 0.000646394
p_wrong: 0.000085958
Score: 0.173
Data Source: BioPlex,STRINGDB
CBLN4
Tbio
Novelty: 0.16541748
p_int: 0.983124519
p_ni: 0.016802381
p_wrong: 0.000073099
Score: 0.437
Data Source: BioPlex,STRINGDB
MSMB
Tbio
Novelty: 0.00164465
p_int: 0.806110364
p_ni: 0.002263217
p_wrong: 0.19162642
Data Source: BioPlex
RLN1
Tbio
Novelty: 0.05712331
p_int: 0.805962712
p_ni: 0.017132175
p_wrong: 0.176905113
Data Source: BioPlex
LGI1
Tbio
Novelty: 0.00246541
Score: 0.96
Data Source: Reactome,STRINGDB
LGI4
Tbio
Novelty: 0.11090573
Score: 0.959
Data Source: Reactome,STRINGDB
KANSL1L
Tdark
Novelty: 1.71428571
Score: 0.754
Data Source: STRINGDB
LGI2
Tbio
Novelty: 0.12915129
Score: 0.686
Data Source: STRINGDB
LGI3
Tbio
Novelty: 0.09708738
Score: 0.676
Data Source: STRINGDB
KANSL3
Tbio
Novelty: 0.0036149
Score: 0.65
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.83

PubMed score by year
PubTator Score  24.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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