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Tbio
ADAM23
Disintegrin and metalloproteinase domain-containing protein 23

Protein Summary
Description
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264377
  • ENSP00000264377
  • ENSG00000114948

Symbol
  • MDC3
  • MDC3
  • MDC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.86
transcription factor perturbation
0.84
PubMedID
0.82
histone modification site profile
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.01   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.01   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
LGI1
Tbio
Novelty:  0.00204066
Score:  0.984
Data Source:  Reactome,STRINGDB
LGI2
Tbio
Novelty:  0.09195527
Score:  0.973
Data Source:  Reactome,STRINGDB
LGI3
Tbio
Novelty:  0.07292291
Score:  0.969
Data Source:  Reactome,STRINGDB
LGI4
Tbio
Novelty:  0.09023711
Score:  0.959
Data Source:  Reactome,STRINGDB
CACNG2
Tbio
Family:  IC
Novelty:  0.00808502
Score:  0.936
Data Source:  Reactome,STRINGDB
DLG4
Tchem
Novelty:  0.00057285
Score:  0.936
Data Source:  Reactome,STRINGDB
ADAM22
Tbio
Family:  Enzyme
Novelty:  0.01981755
Score:  0.912
Data Source:  Reactome,STRINGDB
CACNG3
Tbio
Family:  IC
Novelty:  0.32654561
Score:  0.909
Data Source:  Reactome,STRINGDB
CACNG4
Tbio
Family:  IC
Novelty:  0.15976593
Score:  0.905
Data Source:  Reactome,STRINGDB
CACNG8
Tdark
Family:  IC
Novelty:  0.26770379
Score:  0.902
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
LGI-ADAM interactions
Name
Explore in Pharos
Explore in Source
Developmental Biology
LGI-ADAM interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
3
6
69.2
tonsillectomy risk measurement
1
1
0
1.1
29
diet measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
69.2
tonsillectomy risk measurement
0
1.1
29
diet measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 23
VGNC:10543
459898
Macaque
ADAM metallopeptidase domain 23
707757
Mouse
MGI:1345162
23792
Rat
RGD:1305739
301460
Dog
ADAM metallopeptidase domain 23
VGNC:37581
607871
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ADAM metallopeptidase domain 23
Macaque
ADAM metallopeptidase domain 23
Mouse
Rat
Dog
ADAM metallopeptidase domain 23
Publication Statistics
PubMed Score 33.01
PubMed score by year
PubTator Score 27.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title