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Tbio
ADAM23
Disintegrin and metalloproteinase domain-containing protein 23

Protein Classes
Protein Summary
Description
May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264377
  • ENSP00000264377
  • ENSG00000114948

Symbol
  • MDC3
  • MDC3
  • MDC-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.86
transcription factor perturbation
0.84
PubMedID
0.82
histone modification site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.98   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
LGI-ADAM interactions
Name
Explore in Pharos
Explore in Source
Developmental Biology
LGI-ADAM interactions
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (42)
1 – 10 of 42
LGI1
Tbio
Novelty: 0.00246541
Score: 0.984
Data Source: Reactome,STRINGDB
LGI2
Tbio
Novelty: 0.12915129
Score: 0.973
Data Source: Reactome,STRINGDB
LGI3
Tbio
Novelty: 0.09708738
Score: 0.969
Data Source: Reactome,STRINGDB
LGI4
Tbio
Novelty: 0.11090573
Score: 0.959
Data Source: Reactome,STRINGDB
CACNG2
Tbio
Family: IC
Novelty: 0.01171137
Score: 0.936
Data Source: Reactome,STRINGDB
DLG4
Tchem
Novelty: 0.00079421
Score: 0.936
Data Source: Reactome,STRINGDB
ADAM22
Tbio
Family: Enzyme
Novelty: 0.02563058
Score: 0.912
Data Source: Reactome,STRINGDB
CACNG3
Tbio
Family: IC
Novelty: 0.39498433
Score: 0.909
Data Source: Reactome,STRINGDB
CACNG4
Tbio
Family: IC
Novelty: 0.2156611
Score: 0.905
Data Source: Reactome,STRINGDB
CACNG8
Tdark
Family: IC
Novelty: 0.55263158
Score: 0.902
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  24.98

PubMed score by year
PubTator Score  27.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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