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Tdark
TMCC2
Transmembrane and coiled-coil domains protein 2

Protein Summary
Description
May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329800
  • ENSP00000329436
  • ENSG00000133069
  • ENST00000358024
  • ENSP00000350718
  • ENST00000545499
  • ENSP00000437943
  • ENST00000637895
  • ENSP00000490308

Symbol
  • KIAA0481
  • HUCEP11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor
0.69
small molecule perturbation
0.66
disease perturbation
0.62
cell line
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.44   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
8
8
99.7
reticulocyte count
7
4
7
97
platelet count
3
4
3
2.8
96.9
reticulocyte measurement
3
4
4
96.7
mean corpuscular hemoglobin concentration
3
2
3
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
8
99.7
reticulocyte count
7
97
platelet count
3
2.8
96.9
reticulocyte measurement
4
96.7
mean corpuscular hemoglobin concentration
3
95.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domain family 2
VGNC:1676
742878
Macaque
transmembrane and coiled-coil domain family 2
698565
Mouse
MGI:1916125
68875
Rat
RGD:1311960
305095
Dog
transmembrane and coiled-coil domain family 2
VGNC:47429
488569
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane and coiled-coil domain family 2
Macaque
transmembrane and coiled-coil domain family 2
Mouse
Rat
Dog
transmembrane and coiled-coil domain family 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75069-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (51)
1 – 10 of 51
TEX28
Tdark
Novelty:  0.10581423
p_int:  1
Score:  0.159
Data Source:  BioPlex,STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.999999407
p_ni:  5.88e-7
p_wrong:  4e-9
Score:  0.202
Data Source:  BioPlex,STRINGDB
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
p_int:  0.999923553
p_ni:  0.000076446
Score:  0.157
Data Source:  BioPlex,STRINGDB
MARK3
Tchem
Family:  Kinase
Novelty:  0.01304552
p_int:  0.999738921
p_ni:  0.000261079
Score:  0.19
Data Source:  BioPlex,STRINGDB
UHRF1
Tbio
Family:  Epigenetic
Novelty:  0.00482565
p_int:  0.999027767
p_ni:  0.000970241
p_wrong:  0.000001992
Score:  0.163
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.995719013
p_ni:  0.004280986
p_wrong:  1e-9
Data Source:  BioPlex
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.982644126
p_ni:  0.016603351
p_wrong:  0.000752523
Data Source:  BioPlex
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.98227266
p_ni:  0.01772734
Score:  0.176
Data Source:  BioPlex,STRINGDB
CMTR1
Tbio
Family:  Enzyme
Novelty:  0.09259694
p_int:  0.960707793
p_ni:  0.039292207
Score:  0.219
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.955610315
p_ni:  0.044389684
p_wrong:  1e-9
Data Source:  BioPlex
Publication Statistics
PubMed Score  5.44

PubMed score by year
PubTator Score  1.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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