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Tbio
DNAJC6
Putative tyrosine-protein phosphatase auxilin

Protein Summary
Description
Recruits HSPA8/HSC70 to clathrin-coated vesicles and promotes uncoating of clathrin-coated vesicles. Plays a role in clathrin-mediated endocytosis in neurons (By similarity). DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263441
  • ENSP00000263441
  • ENSG00000116675
  • ENST00000371069
  • ENSP00000360108
  • ENST00000395325
  • ENSP00000378735

Symbol
  • KIAA0473
  • DJC6
  • PARK19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
virus perturbation
0.9
PubMedID
0.78
microRNA
0.74
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.34   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.34   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
15
15
99.8
testosterone measurement
3
3
3
85.6
neutrophil count
2
2
2
84.1
leukocyte count
2
2
2
78.7
sum of basophil and neutrophil counts
1
1
1
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
15
99.8
testosterone measurement
3
85.6
neutrophil count
2
84.1
leukocyte count
2
78.7
sum of basophil and neutrophil counts
1
72.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C6
VGNC:6783
456917
Macaque
DnaJ heat shock protein family (Hsp40) member C6
698682
Mouse
MGI:1919935
72685
Rat
RGD:1309900
313409
Dog
DnaJ heat shock protein family (Hsp40) member C6
VGNC:53346
489553
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member C6
Macaque
DnaJ heat shock protein family (Hsp40) member C6
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member C6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75061-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Clathrin-mediated endocytosis (R-HSA-8856828)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Clathrin-mediated endocytosis
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Lysosome Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Clathrin-mediated endocytosis
Golgi Associated Vesicle Biogenesis
Lysosome Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (286)
1 – 10 of 286
GNAT1
Tbio
Novelty:  0.03042002
p_int:  0.999992553
p_ni:  0.000004971
p_wrong:  0.000002475
Score:  0.699
Data Source:  BioPlex,STRINGDB
IL1RL2
Tbio
Novelty:  0.0156461
p_int:  0.999988337
p_ni:  0.000008012
p_wrong:  0.000003651
Score:  0.379
Data Source:  BioPlex,STRINGDB
COX6A1
Tbio
Family:  Enzyme
Novelty:  0.05543187
p_int:  0.99993871
p_ni:  0.00006129
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.998
Data Source:  Reactome,STRINGDB
CLTC
Tbio
Novelty:  0.00256674
Score:  0.996
Data Source:  STRINGDB
CLTCL1
Tbio
Novelty:  0.05667807
Score:  0.988
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.977
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.975
Data Source:  STRINGDB
CLTB
Tbio
Novelty:  0.00931222
Score:  0.974
Data Source:  STRINGDB
CLTA
Tbio
Novelty:  0.01900315
Score:  0.97
Data Source:  STRINGDB
Publication Statistics
PubMed Score  79.34

PubMed score by year
PubTator Score  48.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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