You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SDC3
Syndecan-3

Protein Summary
Description
Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. The protein encoded by this gene belongs to the syndecan proteoglycan family. It may play a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism. Allelic variants of this gene have been associated with obesity. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339394
  • ENSP00000344468
  • ENSG00000162512

Symbol
  • KIAA0468
  • SDCN
  • SYND3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.67
PubMedID
0.66
histone modification site profile
0.65
virus perturbation
0.64
small molecule perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.81   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.81   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (128)
1 – 10 of 128
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.923285259
p_ni:  1e-8
p_wrong:  0.076714731
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.838221724
p_wrong:  0.161778275
Score:  0.27
Data Source:  BioPlex,STRINGDB
PTN
Tchem
Novelty:  0.00129524
Score:  0.991
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.976
Data Source:  STRINGDB
GPC1
Tbio
Novelty:  0.00293087
Score:  0.971
Data Source:  STRINGDB
GPC4
Tbio
Novelty:  0.01319626
Score:  0.967
Data Source:  STRINGDB
GPC2
Tbio
Novelty:  0.02182363
Score:  0.967
Data Source:  STRINGDB
GPC6
Tbio
Novelty:  0.01951872
Score:  0.966
Data Source:  STRINGDB
GPC5
Tbio
Novelty:  0.01257358
Score:  0.965
Data Source:  STRINGDB
HSPG2
Tbio
Family:  Enzyme
Novelty:  0.00159541
Score:  0.963
Data Source:  STRINGDB
Pathways (41)
A tetrasaccharide linker sequence is required for GAG synthesis (R-HSA-1971475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
A tetrasaccharide linker sequence is required for GAG synthesis
Reactome
Cell surface interactions at the vascular wall
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Defective B3GALT6 causes EDSP2 and SEMDJL1
Reactome
Defective B3GAT3 causes JDSSDHD
Name
Explore in Pharos
Explore in Source
A tetrasaccharide linker sequence is required for GAG synthesis
Cell surface interactions at the vascular wall
Chondroitin sulfate/dermatan sulfate metabolism
Defective B3GALT6 causes EDSP2 and SEMDJL1
Defective B3GAT3 causes JDSSDHD
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
1
1
74.2
hip circumference
1
1
1
73.6
sex hormone-binding globulin measurement
2
1
2
56.4
testosterone measurement
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
74.2
hip circumference
1
73.6
sex hormone-binding globulin measurement
2
56.4
testosterone measurement
1
4.6
Find similar targets by:
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syndecan 3
VGNC:1536
744364
Macaque
syndecan 3
704374
Mouse
MGI:1349163
20970
Rat
RGD:621486
116673
Dog
syndecan 3
VGNC:45943
487323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syndecan 3
Macaque
syndecan 3
Mouse
Rat
Dog
syndecan 3
Publication Statistics
PubMed Score 95.81
PubMed score by year
PubTator Score 53.12
PubTator score by year