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Tbio
NOS1AP
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

Protein Classes
Protein Summary
Description
Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4 (By similarity). This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361897
  • ENSP00000355133
  • ENSG00000198929
  • ENST00000493151
  • ENSP00000434988
  • ENST00000530878
  • ENSP00000431586

Symbol
  • CAPON
  • KIAA0464
  • CAPON
  • 6330408P19Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
cell type or tissue
0.8
biological process
0.79
phenotype
0.72
transcription factor
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.64   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.64   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
6
9
1
2.1
99.4
electrocardiography
3
4
109
7.4
97.8
heel bone mineral density
2
2
2
89
PR interval
1
1
0
12.2
85.3
QRS duration
1
1
0
12.2
85.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
1
2.1
99.4
electrocardiography
109
7.4
97.8
heel bone mineral density
2
89
PR interval
0
12.2
85.3
QRS duration
0
12.2
85.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 1 adaptor protein
VGNC:53224
457463
Macaque
nitric oxide synthase 1 adaptor protein
720378
Mouse
MGI:1917979
70729
Rat
RGD:2320873
100361087
Horse
nitric oxide synthase 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:16859]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nitric oxide synthase 1 adaptor protein
Macaque
nitric oxide synthase 1 adaptor protein
Mouse
Rat
Horse
nitric oxide synthase 1 adaptor protein [Source:HGNC Symbol;Acc:HGNC:16859]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75052-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (27)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (118)
1 – 10 of 118
ENTHD1
Tdark
Novelty: 5.29427978
p_int: 0.999999263
p_ni: 7.37e-7
Data Source: BioPlex
NKAP
Tbio
Novelty: 0.04982584
p_int: 0.99999136
p_ni: 0.00000864
Score: 0.711
Data Source: BioPlex,STRINGDB
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.995313694
p_ni: 0.004686304
p_wrong: 2e-9
Data Source: BioPlex
EAF1
Tbio
Novelty: 0.81120425
p_int: 0.993667288
p_ni: 0.00633271
p_wrong: 2e-9
Data Source: BioPlex
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.993455466
p_ni: 0.006544533
Score: 0.153
Data Source: BioPlex,STRINGDB
ZCCHC17
Tbio
Novelty: 0.06999007
p_int: 0.991388386
p_ni: 0.008610547
p_wrong: 0.000001067
Score: 0.525
Data Source: BioPlex,STRINGDB
TFPI2
Tbio
Novelty: 0.00475383
p_int: 0.989736222
p_ni: 0.010261787
p_wrong: 0.000001991
Data Source: BioPlex
DDX41
Tbio
Family: Enzyme
Novelty: 0.01658581
p_int: 0.98853287
p_ni: 0.01146713
Score: 0.773
Data Source: BioPlex,STRINGDB
MDK
Tchem
Novelty: 0.00145301
p_int: 0.986235599
p_ni: 0.013764216
p_wrong: 1.85e-7
Score: 0.539
Data Source: BioPlex,STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
p_int: 0.985404305
p_ni: 0.014595689
p_wrong: 6e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  152.64

PubMed score by year
PubTator Score  116.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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