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Tbio
PLXNA2
Plexin-A2

Protein Summary
Description
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C. [provided by RefSeq, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367033
  • ENSP00000356000
  • ENSG00000076356

Symbol
  • KIAA0463
  • OCT
  • PLXN2
  • OCT
  • PLXN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.98
transcription factor binding site profile
0.85
kinase perturbation
0.81
PubMedID
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.55   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
2
1
0
1.2
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
adolescent idiopathic scoliosis
0
1.2
27.3
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
plexin A2
713800
Mouse
MGI:107684
18845
Rat
RGD:1305325
289392
Dog
plexin A2
VGNC:44719
490270
Horse
plexin A2
VGNC:21601
100051646
Species
Name
OMA
EggNOG
Inparanoid
Macaque
plexin A2
Mouse
Rat
Dog
plexin A2
Horse
plexin A2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (10)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
CRMPs in Sema3A signaling
Reactome
Developmental Biology
Reactome
Other semaphorin interactions
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Name
Explore in Pharos
Explore in Source
Axon guidance
CRMPs in Sema3A signaling
Developmental Biology
Other semaphorin interactions
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (155)
1 – 10 of 155
LACRT
Tbio
Novelty: 0.03333799
p_int: 0.999967747
p_ni: 0.000032253
Score: 0.166
Data Source: BioPlex,STRINGDB
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.99992763
p_ni: 0.00007237
Data Source: BioPlex
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.999901555
p_ni: 0.000098445
Data Source: BioPlex
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.999589712
p_ni: 0.000410288
Data Source: BioPlex
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.997239272
p_ni: 0.002760728
Data Source: BioPlex
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.996470192
p_ni: 0.003529808
Data Source: BioPlex
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.996137812
p_ni: 0.003862188
Data Source: BioPlex
DEFA5
Tbio
Novelty: 0.00863727
p_int: 0.996032055
p_ni: 0.003967945
Data Source: BioPlex
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.993702629
p_ni: 0.006297367
p_wrong: 4e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
SUSD4
Tbio
Novelty: 0.22201938
p_int: 0.988352233
p_ni: 0.011647767
Data Source: BioPlex
Publication Statistics
PubMed Score  49.55

PubMed score by year
PubTator Score  2943.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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