Tbio SRGAP2 SLIT-ROBO Rho GTPase-activating protein 2

Protein Summary

Description

RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O75044
• A2RUF3
• srGAP2

Gene Name

• SRGAP2

Ensembl ID

• ENST00000573034
• ENSP00000459615
• ENSG00000266028

Symbol

• ARHGAP34
• FNBP2
• KIAA0456
• SRGAP2A
• FNBP2
• SRGAP3
• SRGAP2A
• ARHGAP34

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
microRNA	0.93
transcription factor perturbation	0.84
cell line	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Slit-robo Rho Gtpase-activating Protein 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Slit-robo Rho Gtpase-activating Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.13   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.13   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0