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Tbio
SRGAP2
SLIT-ROBO Rho GTPase-activating protein 2

Protein Summary
Description
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000573034
  • ENSP00000459615
  • ENSG00000266028

Symbol
  • ARHGAP34
  • FNBP2
  • KIAA0456
  • SRGAP2A
  • FNBP2
  • SRGAP3
  • SRGAP2A
  • ARHGAP34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
microRNA
0.93
transcription factor perturbation
0.84
cell line
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.83   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.83   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (88)
SRGAP3
Tbio
Family:  Enzyme
Novelty:  0.01913784
p_int:  0.99998912
p_ni:  0.000010231
p_wrong:  6.49e-7
Score:  0.95
Data Source:  BioPlex,STRINGDB
TRIML2
Tdark
Family:  Enzyme
Novelty:  0.38455379
p_int:  0.999421001
p_ni:  0.000189644
p_wrong:  0.000389355
Score:  0.319
Data Source:  BioPlex,STRINGDB
ROBO1
Tbio
Novelty:  0.00494884
Score:  0.974
Data Source:  Reactome,STRINGDB
FMNL1
Tbio
Novelty:  0.02318884
Score:  0.969
Data Source:  Reactome,STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.957
Data Source:  Reactome,STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.955
Data Source:  Reactome,STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.942
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.94
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.936
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.933
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Inactivation of CDC42 and RAC1
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Inactivation of CDC42 and RAC1
RHO GTPase Effectors
RHO GTPases Activate Formins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
1
3
78.3
3
3
2
1
64.3
serum non-albumin protein measurement
1
1
1
57.3
eosinophil percentage of leukocytes
1
1
1
54.4
eosinophil count
1
1
1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
3
78.3
2
1
64.3
serum non-albumin protein measurement
1
57.3
eosinophil percentage of leukocytes
1
54.4
eosinophil count
1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
SLIT-ROBO Rho GTPase activating protein 2
695724
Mouse
MGI:109605
14270
Rat
RGD:1566016
360840
Dog
SLIT-ROBO Rho GTPase activating protein 2
478949
Horse
SLIT-ROBO Rho GTPase activating protein 2
100050923
Species
Name
OMA
EggNOG
Inparanoid
Macaque
SLIT-ROBO Rho GTPase activating protein 2
Mouse
Rat
Dog
SLIT-ROBO Rho GTPase activating protein 2
Horse
SLIT-ROBO Rho GTPase activating protein 2
Publication Statistics
PubMed Score 38.83
PubMed score by year
PubTator Score 23.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title