SRGAP2
SLIT-ROBO Rho GTPase-activating protein 2
Protein Summary
RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The e ...more
- ENST00000573034
- ENSP00000459615
- ENSG00000266028
- ARHGAP34
- FNBP2
- KIAA0456
- SRGAP2A
- FNBP2
- SRGAP3
- SRGAP2A
- ARHGAP34
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.95 | ||
microRNA | 0.93 | ||
transcription factor perturbation | 0.84 | ||
cell line | 0.74 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.83 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.83 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (88)
SRGAP3
Family: Enzyme
Novelty: 0.01913784
p_int: 0.99998912
p_ni: 0.000010231
p_wrong: 6.49e-7
Score: 0.95
Data Source: BioPlex,STRINGDB
TRIML2
Family: Enzyme
Novelty: 0.38455379
p_int: 0.999421001
p_ni: 0.000189644
p_wrong: 0.000389355
Score: 0.319
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
Reactome (9)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | Inactivation of CDC42 and RAC1 | ||||
Reactome | RHO GTPase Effectors | ||||
Reactome | RHO GTPases Activate Formins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
Inactivation of CDC42 and RAC1 | ||||
RHO GTPase Effectors | ||||
RHO GTPases Activate Formins | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (4)
Components (10)
Processes (12)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 1 | 3 | 78.3 | |||||
3 | 3 | 2 | 1 | 64.3 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 57.3 | |||||
eosinophil percentage of leukocytes | 1 | 1 | 1 | 54.4 | |||||
eosinophil count | 1 | 1 | 1 | 46.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 78.3 | |||||
2 | 1 | 64.3 | |||||
serum non-albumin protein measurement | 1 | 57.3 | |||||
eosinophil percentage of leukocytes | 1 | 54.4 | |||||
eosinophil count | 1 | 46.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | SLIT-ROBO Rho GTPase activating protein 2 | 695724 | ||||||
Mouse | MGI:109605 | 14270 | ||||||
Rat | RGD:1566016 | 360840 | ||||||
Dog | SLIT-ROBO Rho GTPase activating protein 2 | 478949 | ||||||
Horse | SLIT-ROBO Rho GTPase activating protein 2 | 100050923 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | SLIT-ROBO Rho GTPase activating protein 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | SLIT-ROBO Rho GTPase activating protein 2 | |||||
Horse | SLIT-ROBO Rho GTPase activating protein 2 | |||||
Publication Statistics
PubMed Score 38.83
PubMed score by year
PubTator Score 23.58
PubTator score by year
Related Publications
Text Mined References (33)
GeneRif Annotations (14)
Items per page:
0 of 0
PMID | Year | Title |
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