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Tbio
HSF2BP
Heat shock factor 2-binding protein

Protein Summary
Description
May be involved in modulating HSF2 activation in testis (PubMed:9651507). Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm (By similarity). HSF2 binding protein (HSF2BP) associates with HSF2. The interaction occurs between the trimerization domain of HSF2 and the amino terminal hydrophilic region of HSF2BP that comprises two leucine zipper motifs. HSF2BP may therefore be involved in modulating HSF2 activation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291560
  • ENSP00000291560
  • ENSG00000160207
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
transcription factor binding site profile
0.67
PubMedID
0.55
histone modification site profile
0.54
small molecule perturbation
0.53


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.57   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
72.3
eosinophil count
2
2
2
59.4
mean reticulocyte volume
1
1
1
53.7
mean corpuscular volume
1
1
1
44.2
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
72.3
eosinophil count
2
59.4
mean reticulocyte volume
1
53.7
mean corpuscular volume
1
44.2
0
1.1
24.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock transcription factor 2 binding protein
VGNC:1148
474030
Macaque
heat shock transcription factor 2 binding protein
722276
Mouse
MGI:1921627
74377
Rat
RGD:1565879
499413
Dog
heat shock transcription factor 2 binding protein
VGNC:41816
611230
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock transcription factor 2 binding protein
Macaque
heat shock transcription factor 2 binding protein
Mouse
Rat
Dog
heat shock transcription factor 2 binding protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75031-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (31)
1 – 10 of 31
TMEM183A
Tdark
Novelty:  0.4017284
Score:  0.81
Data Source:  STRINGDB
HSF5
Tbio
Family:  TF
Novelty:  0.05786561
Score:  0.761
Data Source:  STRINGDB
SHISA7
Tdark
Novelty:  0.31303212
Score:  0.724
Data Source:  STRINGDB
AMZ2
Tdark
Family:  Enzyme
Novelty:  0.27424719
Score:  0.703
Data Source:  STRINGDB
VRK2
Tbio
Family:  Kinase
Novelty:  0.03300582
Score:  0.686
Data Source:  STRINGDB
RNF13
Tbio
Family:  Enzyme
Novelty:  0.09764564
Score:  0.606
Data Source:  STRINGDB
AP5Z1
Tbio
Family:  TF
Novelty:  0.14368974
Score:  0.604
Data Source:  STRINGDB
UMODL1
Tbio
Novelty:  0.1739838
Score:  0.602
Data Source:  STRINGDB
RRP1B
Tbio
Novelty:  0.08490415
Score:  0.589
Data Source:  STRINGDB
HSF2
Tbio
Family:  TF
Novelty:  0.06458223
Score:  0.577
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.57

PubMed score by year
PubTator Score  0.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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