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Tbio
ABCB7
ATP-binding cassette sub-family B member 7, mitochondrial

Protein Summary
Description
Could be involved in the transport of heme from the mitochondria to the cytosol. Plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253577
  • ENSP00000253577
  • ENSG00000131269
  • ENST00000339447
  • ENSP00000343849
  • ENST00000373394
  • ENSP00000362492
  • ENST00000645829
  • ENSP00000496526

Symbol
  • ABC7
  • ABC7
  • ASAT
  • Atm1p
  • EST140535
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
histone modification site profile
0.88
disease perturbation
0.87
transcription factor perturbation
0.74
protein domain
0.73


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.22   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.22   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily B member 7
704034
Mouse
MGI:109533
11306
Rat
RGD:1303086
302395
Dog
ATP binding cassette subfamily B member 7
VGNC:37435
491967
Horse
ATP binding cassette subfamily B member 7
VGNC:14911
100060544
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ATP binding cassette subfamily B member 7
Mouse
Rat
Dog
ATP binding cassette subfamily B member 7
Horse
ATP binding cassette subfamily B member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75027-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
ABC-family proteins mediated transport (R-HSA-382556)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC-family proteins mediated transport
Reactome
Cytosolic iron-sulfur cluster assembly
Reactome
Metabolism
Reactome
Mitochondrial ABC transporters
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
ABC-family proteins mediated transport
Cytosolic iron-sulfur cluster assembly
Metabolism
Mitochondrial ABC transporters
Transport of small molecules
Protein-Protein Interactions (104)
1 – 10 of 104
NUBP1
Tbio
Novelty: 0.03429412
Score: 0.987
Data Source: STRINGDB
NUBP2
Tbio
Novelty: 0.01136095
Score: 0.965
Data Source: STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
Score: 0.946
Data Source: STRINGDB
GLRX5
Tbio
Novelty: 0.01166161
Score: 0.887
Data Source: STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.876
Data Source: STRINGDB
NFS1
Tbio
Family: Enzyme
Novelty: 0.01274706
Score: 0.868
Data Source: STRINGDB
HSCB
Tbio
Novelty: 0.01330125
Score: 0.866
Data Source: STRINGDB
SLC25A37
Tbio
Family: Transporter
Novelty: 0.01327453
Score: 0.864
Data Source: STRINGDB
ISCU
Tbio
Novelty: 0.0043097
Score: 0.862
Data Source: STRINGDB
ISCA1
Tbio
Novelty: 0.01288069
Score: 0.84
Data Source: STRINGDB
Publication Statistics
PubMed Score  105.22

PubMed score by year
PubTator Score  329.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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