Tbio FCGR3B Low affinity immunoglobulin gamma Fc region receptor III-B

Protein Summary

Description

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]

Uniprot Accession IDs

• O75015

Gene Name

• FCGR3B

Ensembl ID

• ENST00000294800
• ENSP00000294800
• ENSG00000162747
• ENST00000367964
• ENSP00000356941

Symbol

• CD16B
• FCG3
• FCGR3
• IGFR3
• CD16
• FCG3
• CD16A
• CD16b
• FCGR3
• FCGR3A
• FCR-10
• FCRIII
• FCRIIIb

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	0.81
biological term	0.79
microRNA	0.79
PubMedID	0.74
disease	0.67

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-b

DTO Classes

Protein / Cell Adhesion / Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2421.12   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 539   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2421.12   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0