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Tbio
RNGTT
mRNA-capping enzyme

Protein Summary
Description
Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the gmp moiety of GTP to the 5'-diphosphate terminus.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369475
  • ENSP00000358487
  • ENSG00000111880
  • ENST00000369485
  • ENSP00000358497
  • ENST00000538899
  • ENSP00000442609

Symbol
  • CAP1A
  • HCE
  • HCE1
  • hCAP
  • CAP1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.97
disease perturbation
0.95
kinase perturbation
0.93
histone modification site profile
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.76   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.76   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0