You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SCN2B
Sodium channel subunit beta-2

Protein Summary
Description
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or sudden infant death syndrome. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278947
  • ENSP00000278947
  • ENSG00000149575

Symbol
  • ATFB14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
protein domain
0.85
microRNA
0.72
PubMedID
0.63
biological process
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.91   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 253   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.91   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 253   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
sodium voltage-gated channel beta subunit 2
678698
Mouse
MGI:106921
72821
Rat
RGD:3633
25349
Dog
sodium voltage-gated channel beta subunit 2
VGNC:45917
403485
Horse
sodium voltage-gated channel beta subunit 2
VGNC:22735
100062848
Species
Name
OMA
EggNOG
Inparanoid
Macaque
sodium voltage-gated channel beta subunit 2
Mouse
Rat
Dog
sodium voltage-gated channel beta subunit 2
Horse
sodium voltage-gated channel beta subunit 2
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60939-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Protein-Protein Interactions (152)
1 – 10 of 152
RNF213
Tbio
Family: Enzyme
Novelty: 0.00588778
p_int: 0.999999794
p_ni: 2.06e-7
Data Source: BioPlex
RBFA
Tbio
Novelty: 0.1061138
p_int: 0.999993106
p_ni: 0.000005269
p_wrong: 0.000001625
Data Source: BioPlex
RRP1
Tbio
Novelty: 0.12984245
p_int: 0.999986779
p_ni: 0.000013221
Data Source: BioPlex
SLC25A51
Tdark
Family: Transporter
Novelty: 0.21568087
p_int: 0.99997575
p_ni: 0.000024246
p_wrong: 4e-9
Data Source: BioPlex
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
p_int: 0.999954521
p_ni: 0.000045479
Data Source: BioPlex
FOCAD
Tbio
Novelty: 0.14213271
p_int: 0.999952093
p_ni: 0.000036578
p_wrong: 0.00001133
Score: 0.186
Data Source: BioPlex,STRINGDB
ORC5
Tbio
Novelty: 0.02264865
p_int: 0.999930718
p_ni: 0.000069278
p_wrong: 4e-9
Data Source: BioPlex
PTPRF
Tchem
Family: Enzyme
Novelty: 0.01017327
p_int: 0.999647099
p_ni: 0.000352901
p_wrong: 1e-9
Data Source: BioPlex
FAM118B
Tdark
Novelty: 0.48168976
p_int: 0.999482488
p_ni: 0.000517512
Data Source: BioPlex
ITPK1
Tbio
Family: Kinase
Novelty: 0.02790263
p_int: 0.999467125
p_ni: 0.000473064
p_wrong: 0.000059811
Score: 0.181
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.91

PubMed score by year
PubTator Score  11.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer