Tbio KERA Keratocan

Protein Summary

Description

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]

Uniprot Accession IDs

• O60938
• KTN

Gene Name

• KERA

Ensembl ID

• ENST00000266719
• ENSP00000266719
• ENSG00000139330

Symbol

• SLRR2B
• KTN
• CNA2
• SLRR2B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.93
cell type or tissue	0.82
gene perturbation	0.61
cell line	0.59
cellular component	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.79   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.79   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0