Protein Classes
Protein Summary
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of ...more
- ENST00000265433
- ENSP00000265433
- ENSG00000104320
- NBS
- NBS1
- P95
- ATV
- NBS
- P95
- NBS1
- AT-V1
- AT-V2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.97 | ||
disease perturbation | 0.96 | ||
transcription factor perturbation | 0.91 | ||
biological process | 0.9 | ||
transcription factor binding site profile | 0.86 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 146.42 (req: < 5)
Gene RIFs: 283 (req: <= 3)
Antibodies: 1327 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 146.42 (req: >= 5)
Gene RIFs: 283 (req: > 3)
Antibodies: 1327 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 31
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 1 | 2 | 72.3 | |||||
monocyte count | 1 | 1 | 1 | 39.6 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 14.3 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 2 | 72.3 | |||||
monocyte count | 1 | 39.6 | |||||
lymphocyte percentage of leukocytes | 1 | 14.3 | |||||
Orthologs (11)
Protein Structure (1 Structure, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (51)
Reactome (34)
KEGG (2)
PathwayCommons (6)
WikiPathways (9)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 34
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle Checkpoints | ||||
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle Checkpoints | ||||
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Gene Ontology Terms (41)
Functions (3)
Components (10)
Processes (28)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Protein-Protein Interactions (215)
1 – 10 of 215
FAM219A
Novelty: 12.35294118
p_int: 0.999999916
p_ni: 4.7e-8
p_wrong: 3.6e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
BMP1
Novelty: 0.00299518
p_int: 0.99999689
p_ni: 0.00000311
Score: 0.195
Data Source: BioPlex,STRINGDB
CELA2B
Family: Enzyme
Novelty: 0.43122129
p_int: 0.999996816
p_ni: 0.000003183
p_wrong: 1e-9
Score: 0.248
Data Source: BioPlex,STRINGDB
RGS20
Novelty: 0.04087618
p_int: 0.99995272
p_ni: 0.00004725
p_wrong: 3e-8
Score: 0.156
Data Source: BioPlex,STRINGDB
RORC
Family: NR
Novelty: 0.00509106
p_int: 0.999950595
p_ni: 0.000049402
p_wrong: 3e-9
Data Source: BioPlex
PBXIP1
Novelty: 0.15404864
p_int: 0.99989685
p_ni: 0.000103141
p_wrong: 9e-9
Data Source: BioPlex
RAB43
Family: Enzyme
Novelty: 0.07527576
p_int: 0.999691176
p_ni: 0.00030702
p_wrong: 0.000001804
Data Source: BioPlex
LZTS2
Novelty: 0.09515452
p_int: 0.999305404
p_ni: 0.000694534
p_wrong: 6.1e-8
Data Source: BioPlex
TERF2
Family: TF
Novelty: 0.01003649
Score: 0.999
Data Source: STRINGDB
MRE11
Novelty: 0.01038348
Score: 0.999
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 146.42
PubMed score by year
PubTator Score 1173.04
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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