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Tbio
NBN
Nibrin

Protein Summary
Description
Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265433
  • ENSP00000265433
  • ENSG00000104320

Symbol
  • NBS
  • NBS1
  • P95
  • ATV
  • NBS
  • P95
  • NBS1
  • AT-V1
  • AT-V2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
disease perturbation
0.96
transcription factor perturbation
0.91
biological process
0.9
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.31   (req: < 5)
Gene RIFs: 283   (req: <= 3)
Antibodies: 1327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.31   (req: >= 5)
Gene RIFs: 283   (req: > 3)
Antibodies: 1327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (215)
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.999999916
p_ni:  4.7e-8
p_wrong:  3.6e-8
Score:  0.198
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.99999689
p_ni:  0.00000311
Score:  0.195
Data Source:  BioPlex,STRINGDB
CELA2B
Tdark
Family:  Enzyme
Novelty:  0.43122129
p_int:  0.999996816
p_ni:  0.000003183
p_wrong:  1e-9
Score:  0.248
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.99995272
p_ni:  0.00004725
p_wrong:  3e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
RORC
Tchem
Family:  NR
Novelty:  0.00509106
p_int:  0.999950595
p_ni:  0.000049402
p_wrong:  3e-9
Data Source:  BioPlex
PBXIP1
Tbio
Novelty:  0.15404864
p_int:  0.99989685
p_ni:  0.000103141
p_wrong:  9e-9
Data Source:  BioPlex
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.999691176
p_ni:  0.00030702
p_wrong:  0.000001804
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.999305404
p_ni:  0.000694534
p_wrong:  6.1e-8
Data Source:  BioPlex
TERF2
Tchem
Family:  TF
Novelty:  0.01003649
Score:  0.999
Data Source:  STRINGDB
MRE11
Tbio
Novelty:  0.01038348
Score:  0.999
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (51)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
70.5
smoking status measurement
2
2
2
64
lymphocyte percentage of leukocytes
1
1
1
37.6
diastolic blood pressure
1
1
1
7.6
2
1
0
1.1
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
70.5
smoking status measurement
2
64
lymphocyte percentage of leukocytes
1
37.6
diastolic blood pressure
1
7.6
0
1.1
4.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nibrin
VGNC:836
464278
Macaque
nibrin
695912
Mouse
MGI:1351625
27354
Rat
RGD:621420
85482
Dog
nibrin
611315
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nibrin
Macaque
nibrin
Mouse
Rat
Dog
nibrin
Publication Statistics
PubMed Score 147.31
PubMed score by year
PubTator Score 1173.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title