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Tbio
PFDN1
Prefoldin subunit 1

Protein Summary
Description
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261813
  • ENSP00000261813
  • ENSG00000113068

Symbol
  • PFD1
  • PDF
  • PFD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
disease perturbation
0.93
kinase perturbation
0.93
phenotype
0.85
histone modification site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
1
3
95.1
intelligence
2
3
1
6.1
81.9
worry measurement
1
1
0
5.7
19.8
1
1
0
1.1
4.6
reaction time measurement
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
95.1
intelligence
1
6.1
81.9
worry measurement
0
5.7
19.8
0
1.1
4.6
reaction time measurement
1
4.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 1
VGNC:13562
462112
Macaque
prefoldin subunit 1
697795
Mouse
MGI:1914449
67199
Rat
RGD:1305603
361310
Dog
prefoldin subunit 1
606872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prefoldin subunit 1
Macaque
prefoldin subunit 1
Mouse
Rat
Dog
prefoldin subunit 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60925-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Chaperonin-mediated protein folding (R-HSA-390466)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chaperonin-mediated protein folding
Reactome
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Reactome
Metabolism of proteins
Reactome
Prefoldin mediated transfer of substrate to CCT/TriC
Reactome
Protein folding
Name
Explore in Pharos
Explore in Source
Chaperonin-mediated protein folding
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Metabolism of proteins
Prefoldin mediated transfer of substrate to CCT/TriC
Protein folding
Protein-Protein Interactions (119)
1 – 10 of 119
PFDN4
Tbio
Novelty: 0.02133605
p_int: 0.999879815
p_ni: 0.000120185
Score: 0.999
Data Source: BioPlex,STRINGDB
PFDN2
Tbio
Novelty: 0.08537716
p_int: 0.998396189
p_ni: 0.001603811
Score: 0.999
Data Source: BioPlex,STRINGDB
GNB2
Tbio
Novelty: 0.08682553
p_int: 0.98402921
p_ni: 0.01597079
Score: 0.316
Data Source: BioPlex,STRINGDB
KLHDC2
Tbio
Novelty: 0.01485159
p_int: 0.926670776
p_ni: 0.073329224
Score: 0.313
Data Source: BioPlex,STRINGDB
DCAF5
Tdark
Novelty: 0.39565074
p_int: 0.923140554
p_ni: 0.076859446
Score: 0.547
Data Source: BioPlex,STRINGDB
VBP1
Tbio
Novelty: 0.0428293
p_int: 0.918377222
p_ni: 0.081622778
Score: 0.999
Data Source: BioPlex,STRINGDB
PRKAG3
Tbio
Family: Enzyme
Novelty: 0.01865144
p_int: 0.83541467
p_ni: 0.16458533
Score: 0.214
Data Source: BioPlex,STRINGDB
PFDN5
Tbio
Novelty: 0.07673574
Score: 0.999
Data Source: STRINGDB
PFDN6
Tbio
Novelty: 0.01632101
Score: 0.999
Data Source: STRINGDB
TCP1
Tbio
Novelty: 0.00395241
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  11.85

PubMed score by year
PubTator Score  8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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