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Tchem
CTSV
Cathepsin L2

Protein Summary
Description
Cysteine protease. May have an important role in corneal physiology. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259470
  • ENSP00000259470
  • ENSG00000136943
  • ENST00000538255
  • ENSP00000445052

Symbol
  • CATL2
  • CTSL2
  • CTSU
  • CTSU
  • CATL2
  • CTSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
disease perturbation
0.87
protein domain
0.85
cellular component
0.84
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.79   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 168.79   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1