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Tchem
CTSV
Cathepsin L2

Protein Summary
Description
Cysteine protease. May have an important role in corneal physiology. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259470
  • ENSP00000259470
  • ENSG00000136943
  • ENST00000538255
  • ENSP00000445052

Symbol
  • CATL2
  • CTSL2
  • CTSU
  • CTSU
  • CATL2
  • CTSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
disease perturbation
0.87
protein domain
0.85
cellular component
0.84
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.77   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.77   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
boceprevir
chemical structure image
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (27)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Adaptive Immune System
Antigen processing-Cross presentation
Assembly of collagen fibrils and other multimeric structures
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (106)
1 – 10 of 106
CST1
Tbio
Novelty: 0.02481888
p_int: 0.99920657
p_ni: 0.00079343
Score: 0.303
Data Source: BioPlex,STRINGDB
TEFM
Tbio
Novelty: 0.13341034
p_int: 0.998784631
p_ni: 0.001215364
p_wrong: 5e-9
Data Source: BioPlex
TBC1D22B
Tbio
Novelty: 6
p_int: 0.996882477
p_ni: 0.003117518
p_wrong: 5e-9
Data Source: BioPlex
ZIC1
Tbio
Family: TF
Novelty: 0.00309271
p_int: 0.996559467
p_ni: 0.003440527
p_wrong: 6e-9
Data Source: BioPlex
ZSCAN12
Tdark
Family: TF
Novelty: 0.40909091
p_int: 0.996438671
p_ni: 0.003561328
p_wrong: 1e-9
Data Source: BioPlex
VNN2
Tbio
Novelty: 0.02727863
p_int: 0.994948582
p_ni: 0.005051415
p_wrong: 4e-9
Data Source: BioPlex
CSTA
Tbio
Novelty: 0.00454682
p_int: 0.993916843
p_ni: 0.005965065
p_wrong: 0.000118092
Score: 0.861
Data Source: BioPlex,STRINGDB
KNG1
Tchem
Novelty: 0.00008572
p_int: 0.989946728
p_ni: 0.010053272
Score: 0.564
Data Source: BioPlex,STRINGDB
CCDC103
Tbio
Novelty: 0.007955
p_int: 0.973790295
p_ni: 0.026209705
Data Source: BioPlex
FTH1
Tbio
Novelty: 0.00088724
p_int: 0.973265118
p_ni: 0.026734881
Score: 0.208
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  58.77

PubMed score by year
PubTator Score  39.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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