You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
CTSV
Cathepsin L2

Protein Summary
Description
Cysteine protease. May have an important role in corneal physiology. The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259470
  • ENSP00000259470
  • ENSG00000136943
  • ENST00000538255
  • ENSP00000445052

Symbol
  • CATL2
  • CTSL2
  • CTSU
  • CTSU
  • CATL2
  • CTSL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
disease perturbation
0.87
protein domain
0.85
cellular component
0.84
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.91   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 341   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.91   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 341   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 64
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
1 – 1 of 1
boceprevir
Rendered image for boceprevir
Protein-Protein Interactions (106)
1 – 10 of 106
CST1
Tbio
Novelty:  0.02399609
p_int:  0.99920657
p_ni:  0.00079343
Score:  0.303
Data Source:  BioPlex,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.998784631
p_ni:  0.001215364
p_wrong:  5e-9
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.996882477
p_ni:  0.003117518
p_wrong:  5e-9
Data Source:  BioPlex
ZIC1
Tbio
Family:  TF
Novelty:  0.00491601
p_int:  0.996559467
p_ni:  0.003440527
p_wrong:  6e-9
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.996438671
p_ni:  0.003561328
p_wrong:  1e-9
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.994948582
p_ni:  0.005051415
p_wrong:  4e-9
Data Source:  BioPlex
CSTA
Tbio
Novelty:  0.00453121
p_int:  0.993916843
p_ni:  0.005965065
p_wrong:  0.000118092
Score:  0.861
Data Source:  BioPlex,STRINGDB
KNG1
Tbio
Novelty:  0.00007684
p_int:  0.989946728
p_ni:  0.010053272
Score:  0.564
Data Source:  BioPlex,STRINGDB
CCDC103
Tbio
Novelty:  0.07857649
p_int:  0.973790295
p_ni:  0.026209705
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.973265118
p_ni:  0.026734881
Score:  0.208
Data Source:  BioPlex,STRINGDB
Pathways (27)
Activation of Matrix Metalloproteinases (R-HSA-1592389)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of Matrix Metalloproteinases
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Activation of Matrix Metalloproteinases
Adaptive Immune System
Antigen processing-Cross presentation
Assembly of collagen fibrils and other multimeric structures
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (32)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathepsin V
VGNC:4667
107976728
Macaque
cathepsin V
710850
Mouse
MGI:88564
13039
Horse
cathepsin V
100061234
Cow
cathepsin V
281108
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathepsin V
Macaque
cathepsin V
Mouse
Horse
cathepsin V
Cow
cathepsin V
Publication Statistics
PubMed Score 112.91
PubMed score by year
PubTator Score 39.29
PubTator score by year