Tbio TBL1X F-box-like/WD repeat-containing protein TBL1X

Protein Summary

Description

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272). The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• O60907
• A8K044
• A8K4J7
• Q86UY2

Gene Name

• TBL1X

Ensembl ID

• ENST00000217964
• ENSP00000217964
• ENSG00000101849
• ENST00000380961
• ENSP00000370348
• ENST00000407597
• ENSP00000385988
• ENST00000424279
• ENSP00000394097
• ENST00000645353
• ENSP00000496215
• ENST00000645686
• ENSP00000493782
• ENST00000646640
• ENSP00000495556

Symbol

• TBL1
• EBI
• TBL1
• SMAP55

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
transcription factor binding site profile	0.95
protein domain	0.92
biological process	0.85
transcription factor	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4180.88   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 188   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4180.88   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0