Tclin RAMP3 Receptor activity-modifying protein 3

Protein Summary

Description

Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60896
• Q7Z2Y1

Gene Name

• RAMP3

Ensembl ID

• ENST00000242249
• ENSP00000242249
• ENSG00000122679
• ENST00000481345
• ENSP00000419012

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.86
gene perturbation	0.84
tissue sample	0.68
cellular component	0.61
PubMedID	0.57

Protein Classes

PANTHER Classes

Protein / Receptor / Receptor Activity-modifying Protein 3

DTO Classes

Protein / Receptor / Receptor Activity-modifying Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.83   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 182   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.83   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1