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Tclin
RAMP2
Receptor activity-modifying protein 2

Protein Classes
Protein Summary
Description
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253796
  • ENSP00000253796
  • ENSG00000131477
  • ENST00000587142
  • ENSP00000466455
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
0.89
disease perturbation
0.79
cell type or tissue
0.76
gene perturbation
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.85   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.85   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
pramlintide
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
71.5
2
1
1
1.1
45.9
pulse pressure measurement
1
1
1
9.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
71.5
1
1.1
45.9
pulse pressure measurement
1
9.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
receptor activity modifying protein 2
VGNC:9553
454698
Macaque
receptor activity modifying protein 2
707718
Mouse
MGI:1859650
54409
Rat
RGD:61872
58966
Dog
receptor activity modifying protein 2
480515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
receptor activity modifying protein 2
Macaque
receptor activity modifying protein 2
Mouse
Rat
Dog
receptor activity modifying protein 2
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (9)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (138)
1 – 10 of 138
CALCRL
Tclin
Family: GPCR
Novelty: 0.00568602
Score: 0.999
Data Source: Reactome,STRINGDB
ADM
Tbio
Novelty: 0.0004958
Score: 0.991
Data Source: Reactome,STRINGDB
IAPP
Tbio
Novelty: 0.0005195
Score: 0.986
Data Source: Reactome,STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.985
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.985
Data Source: STRINGDB
ADM2
Tbio
Novelty: 0.00245573
Score: 0.976
Data Source: Reactome,STRINGDB
CALCR
Tclin
Family: GPCR
Novelty: 0.00112487
Score: 0.975
Data Source: Reactome,STRINGDB
CALCB
Tclin
Novelty: 0.02069808
Score: 0.974
Data Source: STRINGDB
VIPR1
Tchem
Family: GPCR
Novelty: 0.0016529
Score: 0.967
Data Source: STRINGDB
GCGR
Tclin
Family: GPCR
Novelty: 0.00392059
Score: 0.966
Data Source: STRINGDB
Publication Statistics
PubMed Score  103.85

PubMed score by year
PubTator Score  66.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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