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Tclin
RAMP1
Receptor activity-modifying protein 1

Protein Classes
Protein Summary
Description
Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL. The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. Alternative splicing resu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254661
  • ENSP00000254661
  • ENSG00000132329
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
gene perturbation
0.81
biological process
0.79
PubMedID
0.73
molecular function
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.61   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 185.61   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
pramlintide
Rendered image for pramlintide
erenumab
no chemical structure image available
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
49.5
apolipoprotein A 1 measurement
1
1
1
24.5
sleep measurement
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
49.5
apolipoprotein A 1 measurement
1
24.5
sleep measurement
1
4.2
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1858418
51801
Rat
RGD:61870
58965
Dog
receptor activity modifying protein 1 [Source:HGNC Symbol;Acc:HGNC:9843]
Horse
receptor activity modifying protein 1
VGNC:22168
100066550
Cow
receptor activity modifying protein 1
617017
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
receptor activity modifying protein 1 [Source:HGNC Symbol;Acc:HGNC:9843]
Horse
receptor activity modifying protein 1
Cow
receptor activity modifying protein 1
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60894-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Calcitonin-like ligand receptors (R-HSA-419812)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (25)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (149)
1 – 10 of 149
SELENOS
Tbio
Novelty:  0.01108715
p_int:  0.999847073
p_ni:  0.00001932
p_wrong:  0.000133607
Data Source:  BioPlex
SLC30A1
Tbio
Family:  Transporter
Novelty:  0.00528427
p_int:  0.99970964
p_ni:  0.000290341
p_wrong:  1.9e-8
Data Source:  BioPlex
CCPG1
Tbio
Novelty:  0.07685013
p_int:  0.999605189
p_ni:  0.000394811
Data Source:  BioPlex
DNAJB9
Tbio
Novelty:  0.00536296
p_int:  0.998341695
p_ni:  0.001658305
Score:  0.641
Data Source:  BioPlex,STRINGDB
FZD2
Tbio
Family:  GPCR
Novelty:  0.00774893
p_int:  0.994816033
p_ni:  0.005179518
p_wrong:  0.00000445
Data Source:  BioPlex
SLC12A7
Tbio
Family:  Transporter
Novelty:  0.02248904
p_int:  0.990030857
p_ni:  0.009968784
p_wrong:  3.59e-7
Data Source:  BioPlex
SGPL1
Tchem
Family:  Enzyme
Novelty:  0.00272574
p_int:  0.986885225
p_ni:  0.013114775
Data Source:  BioPlex
CALCRL
Tclin
Family:  GPCR
Novelty:  0.00568602
p_int:  0.978251144
p_ni:  1.3e-8
p_wrong:  0.021748842
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
p_int:  0.963531525
p_ni:  0.036468461
p_wrong:  1.4e-8
Data Source:  BioPlex
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
p_int:  0.962960337
p_ni:  0.036775012
p_wrong:  0.000264651
Data Source:  BioPlex
Publication Statistics
PubMed Score  185.61

PubMed score by year
PubTator Score  108.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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