Tbio CUTA Protein CutA

Protein Summary

Description

May form part of a complex of membrane proteins attached to acetylcholinesterase (AChE).

Uniprot Accession IDs

• O60888
• A2AB26
• A2BEL4
• Q3B784
• Q5JXM9
• Q5SU05
• Q9NYQ9

Gene Name

• CUTA

Ensembl ID

• ENST00000374496
• ENSP00000363620
• ENSG00000112514
• ENST00000374500
• ENSP00000363624
• ENST00000435267
• ENSP00000391509
• ENSG00000226492
• ENST00000440279
• ENSP00000403268
• ENST00000440930
• ENSP00000400114
• ENST00000487148
• ENSP00000432744
• ENST00000488034
• ENSP00000417544
• ENST00000607266
• ENSP00000475963
• ENST00000611509
• ENSP00000480360

Symbol

• ACHAP
• C6orf82
• ACHAP
• C6orf82

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
disease perturbation	0.9
transcription factor binding site profile	0.84
transcription factor perturbation	0.8
transcription factor	0.77

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Protein Cuta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.05   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 164   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.05   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (46)

Explore Interacting Targets

1 – 10 of 46

• See Interactions on String-DB

UPP1

Tchem

Family:  Enzyme

Novelty:  0.01384975

p_int:  0.999999993

p_ni:  7e-9

p_wrong:  1e-9

Score:  0.297

Data Source:  BioPlex,STRINGDB

PRKAA1

Tclin

Family:  Kinase

Novelty:  0.01205826

p_int:  0.998614332

p_ni:  0.001385668

Score:  0.696

Data Source:  BioPlex,STRINGDB

FBLIM1

Tbio

Novelty:  0.0332985

p_int:  0.998036292

p_ni:  0.001963708

Score:  0.252

Data Source:  BioPlex,STRINGDB

CLTCL1

Tbio

Novelty:  0.05667807

p_int:  0.997784224

p_ni:  0.002215776

Data Source:  BioPlex

UBB

Tbio

Novelty:  0.00661254

p_int:  0.995864567

p_ni:  0.004135433

Score:  0.172

Data Source:  BioPlex,STRINGDB

PRKAB1

Tchem

Family:  Kinase

Novelty:  0.01610606

p_int:  0.991844952

p_ni:  0.008153308

p_wrong:  0.000001739

Score:  0.56

Data Source:  BioPlex,STRINGDB

GID4

Tbio

Novelty:  0.05252674

p_int:  0.981481436

p_ni:  0.018518564

Data Source:  BioPlex

ARMC8

Tbio

Novelty:  0.06820746

p_int:  0.978821154

p_ni:  0.021178846

Data Source:  BioPlex

ZER1

Tbio

Novelty:  0.02989698

p_int:  0.976720146

p_ni:  0.023279854

Score:  0.173

Data Source:  BioPlex,STRINGDB

PRKAG1

Tchem

Family:  Kinase

Novelty:  0.07735301

p_int:  0.953873813

p_ni:  0.046126187

Score:  0.765

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (2)

Components (2)

Processes (2)

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1 – 2 of 2

GO Term	Evidence	Assigned by
enzyme binding	Inferred from Physical Interaction (IPI)	UniProtKB
copper ion binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (12)

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	ENSG ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	ENSG00000226492	3	2	0	1.1	56.6
schizophrenia	EFO_0000692	ENSG00000112514	3	2	0	1.1	56.6
autism spectrum disorder	EFO_0003756	ENSG00000226492	1	2	0	1.1	55.2
autism spectrum disorder	EFO_0003756	ENSG00000112514	1	2	0	1.1	55.2
visceral adipose tissue measurement	EFO_0004765	ENSG00000226492	1	1	1		20.9

Items per page:

5

1 – 5 of 12

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
schizophrenia	EFO_0000692	0	1.1	56.6
schizophrenia	EFO_0000692	0	1.1	56.6
autism spectrum disorder	EFO_0003756	0	1.1	55.2
autism spectrum disorder	EFO_0003756	0	1.1	55.2
visceral adipose tissue measurement	EFO_0004765	1		20.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Complete proteome
Direct protein sequencing
Glycoprotein
Reference proteome
Signal

GWAS Trait Find Similar Targets

No Header	No Header
autism spectrum disorder
body height
C-reactive protein measurement
insomnia measurement
schizophrenia
visceral adipose tissue measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cutA divalent cation tolerance homolog	VGNC:13796	746949
Macaque	cutA divalent cation tolerance homolog		718364
Mouse	cutA divalent cation tolerance homolog	MGI:1914925	67675
Rat	cutA divalent cation tolerance homolog	RGD:1303306	294288
Dog	cutA divalent cation tolerance homolog	VGNC:39736	474874

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cutA divalent cation tolerance homolog
Macaque	cutA divalent cation tolerance homolog
Mouse	cutA divalent cation tolerance homolog
Rat	cutA divalent cation tolerance homolog
Dog	cutA divalent cation tolerance homolog

Publication Statistics

PubMed Score 57.05

PubMed score by year

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PubTator Score 11.82

PubTator score by year

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Related Publications

Text Mined References (18)

GeneRif Annotations (6)

Items per page:

10

0 of 0

PMID	Year	Title