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Tchem
BRD4
Bromodomain-containing protein 4

Protein Summary
Description
Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263377
  • ENSP00000263377
  • ENSG00000141867
  • ENST00000360016
  • ENSP00000353112
  • ENST00000371835
  • ENSP00000360901

Symbol
  • HUNK1
  • CAP
  • MCAP
  • HUNK1
  • HUNKI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
viral protein
1
virus
1
biological process
0.94
co-expressed gene
0.93
interacting protein
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.87   (req: < 5)
Gene RIFs: 179   (req: <= 3)
Antibodies: 374   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 928.87   (req: >= 5)
Gene RIFs: 179   (req: > 3)
Antibodies: 374   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2183
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6
Active Ligands (2183)
1 – 10 of 2183
Belinosta
Rendered image for Belinosta
CHEMBL3220922
Rendered image for CHEMBL3220922
BI-2536
Rendered image for BI-2536
Bromosporine
Rendered image for Bromosporine
LY 294002
Rendered image for LY 294002
CHEMBL4514808
Rendered image for CHEMBL4514808
CHEMBL4173488
Rendered image for CHEMBL4173488
CHEMBL4436408
Rendered image for CHEMBL4436408
Mivebresib
Rendered image for Mivebresib
US9458145, 1020-18
Rendered image for US9458145, 1020-18
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
74
red blood cell density measurement
1
1
1
72.3
reticulocyte measurement
2
2
2
68.1
mean corpuscular volume
1
1
1
63.7
mean reticulocyte volume
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
74
red blood cell density measurement
1
72.3
reticulocyte measurement
2
68.1
mean corpuscular volume
1
63.7
mean reticulocyte volume
1
57.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 4
VGNC:10980
455794
Macaque
bromodomain containing 4
718195
Mouse
MGI:1888520
57261
Rat
RGD:1307282
362844
Dog
bromodomain containing 4
VGNC:38520
484869
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bromodomain containing 4
Macaque
bromodomain containing 4
Mouse
Rat
Dog
bromodomain containing 4
Protein Structure (273 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60885-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 273
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
MGI
Protein-Protein Interactions (239)
1 – 10 of 239
FAM90A1
Tdark
Novelty:  0.95155075
p_int:  1
Score:  0.201
Data Source:  BioPlex,STRINGDB
ATAD5
Tbio
Family:  Enzyme
Novelty:  0.02459839
p_int:  0.999999989
p_ni:  9e-9
p_wrong:  2e-9
Score:  0.432
Data Source:  BioPlex,STRINGDB
GPSM1
Tbio
Novelty:  0.03510582
p_int:  0.99999951
p_ni:  4.89e-7
p_wrong:  1e-9
Score:  0.301
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.999993036
p_ni:  0.000006964
Score:  0.263
Data Source:  BioPlex,STRINGDB
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.999954152
p_ni:  0.000045817
p_wrong:  3.1e-8
Data Source:  BioPlex
CAMKV
Tbio
Family:  Kinase
Novelty:  0.17794181
p_int:  0.99993629
p_ni:  0.00006371
Score:  0.192
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.997336469
p_ni:  0.002663524
p_wrong:  7e-9
Score:  0.664
Data Source:  BioPlex,STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.991168667
p_ni:  0.00880818
p_wrong:  0.000023153
Score:  0.169
Data Source:  BioPlex,STRINGDB
TFCP2
Tbio
Family:  TF
Novelty:  0.00687548
p_int:  0.990794322
p_ni:  0.009205147
p_wrong:  5.31e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
SULF2
Tbio
Family:  Enzyme
Novelty:  0.01536228
p_int:  0.942850815
p_ni:  0.056797236
p_wrong:  0.000351949
Data Source:  BioPlex
Publication Statistics
PubMed Score  928.87

PubMed score by year
PubTator Score  411.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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