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Tbio
DNAJA2
DnaJ homolog subfamily A member 2

Protein Summary
Description
Co-chaperone of Hsc70. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877). The protein encoded by this gene belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain. The product of this gene works as a cochaperone of Hsp70s in protein folding and mitochondrial protein import in vitro. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317089
  • ENSP00000314030
  • ENSG00000069345

Symbol
  • CPR3
  • HIRIP4
  • DJ3
  • CPR3
  • DJA2
  • DNAJ
  • DNJ3
  • RDJ2
  • HIRIP4
  • PRO3015
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
kinase perturbation
0.91
molecular function
0.88
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.2   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.2   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol change measurement
1
1
1
1
response to simvastatin
1
1
1
1
response to fenofibrate
1
1
1
1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol change measurement
1
1
response to simvastatin
1
1
response to fenofibrate
1
1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member A2
VGNC:5749
473274
Macaque
DnaJ heat shock protein family (Hsp40) member A2
716353
Mouse
MGI:1931882
56445
Rat
RGD:71001
84026
Dog
DnaJ heat shock protein family (Hsp40) member A2
478143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DnaJ heat shock protein family (Hsp40) member A2
Macaque
DnaJ heat shock protein family (Hsp40) member A2
Mouse
Rat
Dog
DnaJ heat shock protein family (Hsp40) member A2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60884-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Gene Ontology Terms (12)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (105)
1 – 10 of 105
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.997
Data Source:  Reactome,STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.994
Data Source:  Reactome,STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.991
Data Source:  Reactome,STRINGDB
HSPA1A
Tchem
Novelty:  0.00069195
Score:  0.983
Data Source:  Reactome,STRINGDB
STIP1
Tbio
Novelty:  0.00590952
Score:  0.98
Data Source:  Reactome,STRINGDB
HSPA2
Tchem
Novelty:  0.01696667
Score:  0.967
Data Source:  STRINGDB
HSPA1B
Tbio
Novelty:  0.01429214
Score:  0.965
Data Source:  Reactome,STRINGDB
HSPA1L
Tbio
Novelty:  0.01658161
Score:  0.964
Data Source:  STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.963
Data Source:  STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.962
Data Source:  STRINGDB
Publication Statistics
PubMed Score  40.20

PubMed score by year
PubTator Score  25.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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