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Tbio
GPR37L1
G-protein coupled receptor 37-like 1

Protein Summary
Description
G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367282
  • ENSP00000356251
  • ENSG00000170075

Symbol
  • ETBRLP2
  • ETBRLP2
  • ETBR-LP-2
  • ET(B)R-LP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.64
gene perturbation
0.63
cell line
0.59
tissue
0.5
pathway
0.47


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.72   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 272   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.72   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 272   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 37 like 1
VGNC:8046
457626
Macaque
G protein-coupled receptor 37 like 1
706485
Mouse
MGI:1928503
171469
Rat
RGD:628835
252939
Dog
G protein-coupled receptor 37 like 1
VGNC:41433
607285
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor 37 like 1
Macaque
G protein-coupled receptor 37 like 1
Mouse
Rat
Dog
G protein-coupled receptor 37 like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60883-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (238)
1 – 10 of 238
PSAP
Tbio
Novelty: 0.00395347
Score: 0.963
Data Source: Reactome,STRINGDB
NPY2R
Tchem
Family: GPCR
Novelty: 0.01177255
Score: 0.949
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00099622
Score: 0.931
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.93
Data Source: STRINGDB
GRM3
Tchem
Family: GPCR
Novelty: 0.00340947
Score: 0.924
Data Source: STRINGDB
RXFP3
Tchem
Family: GPCR
Novelty: 0.01844783
Score: 0.922
Data Source: STRINGDB
GRM7
Tchem
Family: GPCR
Novelty: 0.00416377
Score: 0.919
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00827879
Score: 0.918
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.918
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  14.72

PubMed score by year
PubTator Score  5.45

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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